Polypeptide and gene encoding the same

Details Polypeptide and gene encoding the same Polypeptide and gene encoding the same

2005-02-14

2011-10-04

Rawlings, Stephen (Department: 1643)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C530S300000, C530S324000, C530S350000

Reexamination Certificate

active

08030277

ABSTRACT:
A polypeptide having the amino acid sequence as set forth in SEQ ID NO: 2, 4, or 6, a DNA encoding the same, and an antibody against said polypeptide, and the use thereof. The above amino acid sequence has a homology with chondromodulin-I that has an effect of controlling the growth and differentiation of chondrocytes and inhibiting angiogenesis.

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Hiraki, Yuji, et al. “Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its express in Chinese hamster ovary cells”, European Journal of Biochemistry, vol. 260, No. 3, Mar. 1999, pp. 869-878, XP002279021 ISSN: 0014-2956.
Database EBI 'Online! Sep. 14, 1999 Lawlor S.: Human DNA sequence from clone RP3-419J7 on chromosome Xq21.33-23. Contains part of a gene similar to chondromodulin-1. Database accession No. AL035608 XP002279022.
Database EBI 'Online! Est, Dec. 18, 1994 Liew C.C.: “A533F heartHomo sapienscDNA clone A533 similar to chondromodulin, mRNA sequence.” Database accession No. T12179 XP0022979023.
Database EBI 'Online! Est, Mar. 18, 1997 Adams M.D.: “EST112774 Embryo, 12 weekHomo sapienscDNA 5' end similar to chondromodulin 1.” Database accession No. AA297231 XP002279024.
Database EBI 'Online! Est, Jul. 1, 1998 NCI-CGAP: “ox30b10.s1 Soares—total—fetus—Nb2HF8—9wHomo sapienscDNA clone IMAGE: 1657819 3' similar to SW:CHM1—BOVIN P17404 chondromodulin-1, Mrna sequence.” Database accession No. A1039039 XP002279025.
Databse EBI 'Online! Est, Mar. 29, 2000 NCI-CGAP: “ur24h02.y1 Soares—mouse—NMBP Mus musculus cDNA clone IMAGE: 302529 similar to TR:q9yi63 Chondromodulin-1 Precursor, mRNA sequence” Database accession No. AW743952 XP002279026.
Databse EBI 'Online! Est, Jul. 18, 1996 Marra M.: mf97e12.r1 Soares mouse embryo NbME13.5 14.5 Mus musculus cDNA clone IMAGE: 422254 5' similar to SW: CHM1—bovin p17404 chondromodulin-I, mRNA sequence Database accession No. W97621 XP002279027.
Database EBI 'Online! EST, Mar. 4, 2000 Lee N. H.: EST291897 Normalized rat embryo, Bento Soares Rattus sp. cDNA clone 5' end similar to chondromodulin-I, mRNA sequence Database accession No. AW144807 XP002279028.

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