Polypeptide analyses using stable isotope labeling

Chemistry: analytical and immunological testing – Peptide – protein or amino acid

Reexamination Certificate

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C436S056000, C436S057000, C436S019000, C436S120000, C436S173000, C436S161000, C435S007100, C435S007920, C435S024000

Reexamination Certificate

active

07052916

ABSTRACT:
Methods for incorporating a stable isotope into a protein or peptide fragment are disclosed. The methods include providing isolated isotope-labeled protein or peptide fragments and analyzing the isolated labeld fragments. In another aspect of the invention, methods for quantitatively comparing peptides in two protein or peptide fragment mixtures are provided. In these methods, protein levels are measured using stable-isotope coded protein or peptide fragments.

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