Polypeptide analogs of Apolipoprotein E

Details Polypeptide analogs of Apolipoprotein E Polypeptide analogs of Apolipoprotein E

1989-08-18

1993-01-05

Robinson, Douglas W.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

930DIG821, C07K 700, A61K 3700

Patent

active

051771896

ABSTRACT:
The present invention contemplates a multimeric polypeptide capable of mimicking the ability of Apo E in regulating lymphocyte proliferation and ovarian androgen synthesis. The polypeptide has an amino acid residue sequence represented by the formula ##STR1##

REFERENCES:
patent: 4643988 (1987-02-01), Segrest
Rudinger (1976) in "Peptide Hormones", ed. Parsons J. A., pp. 1-7, U. Park Press, Baltimore.
Sutcliffe et al, (1983) Science, 219, 660-666.
Weisgraber et al. (1983) J. Biol. Chem., 258, 12348-12354.
Cardin et al. (1988) Biochem. Biophys. Res. Comm., 154, 741-745.
Sparrow et al. (1985) Biochemistry, 24, 6984-6988.
Epand et al., J. Biol. Chem., 262:9389-9396 (1987).
Segrest, FEBS Lett., 38:247-253 (1974).
Gesquiere et al., Clin. Chem., 31:784-785 (1985).
Mahley et al., Biochim. Biophy. Acta, 737:197-222 (1983).

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