Polypeptide analogs of apolipoprotein E

Details Polypeptide analogs of apolipoprotein E Polypeptide analogs of apolipoprotein E

1990-02-26

1993-01-26

Naff, David M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

514 12, C07K 700, A61K 3702, A61K 3700

Patent

active

051823640

ABSTRACT:
The present invention contemplates a method for treating hypercholesterolemia in a patient, which method comprises administering to the patient an LDL plasma concentration-reducing amount of a multimeric polypeptide capable of binding the LDL receptor. THe repeating unit of the polypeptide has an amino acid residue sequence corresponding to that represented by the formula LRKLRKRLLRDADDL.

REFERENCES:
patent: 4643988 (1987-02-01), Segrest et al.
Segrest et al. (1974) FEBS Lett., 38(3), 247-253.
Cardin et al. (1988) Biochem. Biophys. Res. Comm., 154, 741-745.
Sparrow et al. (1985) Biochemistry, 24, 6984-6988.
Rudinger (1976) in "Peptide Hormones", ed. Parsons, pp. 1-7, Univ. Park Press, Baltimore.
Weisgraber et al. (1983) J. Biol. Chem., 258, 12348-12354.
Sutcliffe et al. (1983) Science, 219, 660-666.
Epand et al. (1987) J. Biol. Chem., 262, 9389-9396.
Gesquiere et al., Clin. Chem., 31:784-785 (1985).
Mahley et al., Biochim. Biophy. Acta., 737:197-222 (1983).

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