Polypeptide absorbable into digestive organs

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Reexamination Certificate

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C424S193100, C435S004000

Reexamination Certificate

active

07910115

ABSTRACT:
A polypeptide absorbable into digestive organs, which is linked with a bioactive polypeptide, and assists absorption of the bioactive polypeptide into digestive organs when it is orally taken; a fusion polypeptide comprising the polypeptide absorbable into digestive organs and the bioactive polypeptide; and an oral composition comprising the fusion polypeptide are provided.

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Mikayama et al. (Nov. 1993. Proc.Natl.Acad.Sci. USA, vol. 90 : 10056-10060).
Rudinger et al. (Jun. 1976. Peptide Hormones. Biol.Council. pp. 5-7).
M.L. Stahl et al., “Replacement of theBacillus subtilissubtilisin structural gene with an in vitro-derived deletion mutation”, Journal of Bacteriology, vol. 158, No. 2, pp. 411-418, May 1984.
T. Nakamura et al., “Nucleotide sequence of the subtilisin NAT gene, aprN, ofBacillus subtilis(natto)”, Biosci. Biotech. Biochem., vol. 56, No. 11, pp. 1869-1871, 1992.

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