Polypeptide

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

Reexamination Certificate

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Details

C435S004000, C435S006120, C435S069100, C435S183000, C435S252300, C435S320100, C435S325000, C435S348000, C435S254100, C435S358000, C435S410000, C536S023200, C536S023500, C536S023700

Reexamination Certificate

active

09744748

ABSTRACT:
This invention relates to a novel polypeptide having an α1,3-fucosyltransferase activity, a method for producing the polypeptide, a DNA encoding the polypeptide, a method for producing the DNA, a recombinant vector obtained by inserting the DNA thereinto, a transformant having the recombinant vector, an antibody recognizing the polypeptide, a method for determining or immunostaining the polypeptide of the present invention using the antibody, a method for producing a fucose-containing sugar chain using the polypeptide or the transformant, a method for screening a substance that changes the expression of a gene encoding the polypeptide, a method for screening a substance that changes the activity of the polypeptide, and a method for diagnosing diseases such as encephalopathy, renal diseases and cancers.

REFERENCES:
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patent: 5625124 (1997-04-01), Falk et al.
patent: 93/16178 (1993-08-01), None
patent: WO94/02616 (1994-02-01), None
patent: 96/40881 (1996-12-01), None
patent: WO97/09421 (1997-03-01), None
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Kudo, et al., “Expression Cloning and Characterization of a Novel Murine . . . ”, The Journal of Biological Chemistry, vol. 273, No. 41, (1998), pp. 26729-26738.
Kaneko, et al., “α1,3-Fucoslytransferase IX (Fuc-TIX) is very highly conserved”, FEBS Letters, vol. 452 (1999), pp. 237-242.
Costache, et al., “Evolution of Fucoslytransferase Genes in Vertebrates”, The Journal of Biological Chemistry, vol. 272, No. 47 (1997), pp. 29721-29728.
Cameron, et al., “Expression of Human Chromosome 19p α(1,3)-Fucoslytransferase . . . ”, The Journal of Biological Chemistry, vol. 270, No. 34 (1995), pp. 20112-20122.
Weston, et al., “Isolation of a Novel Human α(1,3)Fucoslytransferase Gene . . . ”, The Journal of Biological Chemistry, vol. 267, No. 6 (1992), pp. 4152-4160.

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