Polyorganosiloxane having a quaternary salt at its one terminal

Details Polyorganosiloxane having a quaternary salt at its one terminal Polyorganosiloxane having a quaternary salt at its one terminal

1991-11-04

1993-04-06

Marquis, Melvyn I.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From silicon reactant having at least one...

556425, 546 14, C08G 7704

Patent

active

052004880

ABSTRACT:
A polyorganosiloxane having a quaternary salt at its one terminal, of the following formula (I): ##STR1## wherein A is ##STR2## X.sup.- is a counter anion in the quaternary salt; each of R.sup.1 to R.sup.5 which may be the same or different, is an alkyl group, a substituted alkyl group or a phenyl group; Y is a C.sub.1-6 linear or branched bivalent alkylene or oxyalkylene group; and n is an integer of at least 1, provided that when n is 2 or more, each of R.sup.4 and R.sup.5 may be the same or different, wherein each of R.sup.6 to R.sup.8 which may be the same or different, is an alkyl group, a substituted alkyl group or a phenyl group, or R.sup.6 to R.sup.8 together form a ring and/or an unsaturated bond; R is a C.sub.1-6 alkyl group or a phenyl group; m is an integer of from 0 to 3, provided that when m is 2 or 3, R may be the same of different; and each of R.sup.9 to R.sup.11 which may be the same or different, is a phenyl group, a benzyl group or a C.sub.1-6 alkyl group.
Such polyorganosiloxane is useful for promoting percutaneous absorption of a drug.

REFERENCES:
patent: 4093642 (1978-06-01), Schilling et al.
patent: 4472566 (1984-09-01), Ziemelis et al.
patent: 5041590 (1991-08-01), Snow

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