Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Reexamination Certificate
2011-01-18
2011-01-18
Padmanabhan, Sreeni (Department: 1627)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
C424S009351, C514S023000, C514S054000, C514S059000
Reexamination Certificate
active
07871597
ABSTRACT:
Pharmacological compositions, and methods for administration, of the type employing an iron oxide complex with a polyol or polyether. The methods of administration may comprise parenteral administration of an effective dose of the complex formulated in a biocompatible liquid delivered at a rate of from about 1 mL/sec to less than 1 mL/min and wherein upon administration the complex provides minimal detectable free iron in a subject, and minimal incidence of anaphylaxis. The pharmacological compositions are of the type employing a polyol or polyether iron oxide complex, which, upon parenteral administration to a subject, are substantially immunosilent, provide minimal anaphylaxis and minimal free iron, and undergo minimal dissolution in vivo.
REFERENCES:
patent: 2856366 (1958-10-01), Novak et al.
patent: 2856398 (1958-10-01), Novak et al.
patent: 2862920 (1958-12-01), Berger et al.
patent: 2885393 (1959-05-01), Herb
patent: 3000872 (1961-09-01), Novak
patent: 3151107 (1964-09-01), Heckel et al.
patent: 4101435 (1978-07-01), Hasegawa et al.
patent: 4180567 (1979-12-01), Herb
patent: 4452773 (1984-06-01), Molday
patent: 4770183 (1988-09-01), Groman et al.
patent: 4827945 (1989-05-01), Groman et al.
patent: 5055288 (1991-10-01), Lewis et al.
patent: 5076950 (1991-12-01), Ullman et al.
patent: 5102652 (1992-04-01), Groman et al.
patent: 5160726 (1992-11-01), Groman et al.
patent: 5204457 (1993-04-01), Maruno et al.
patent: 5262176 (1993-11-01), Palmacci et al.
patent: 6165378 (2000-12-01), Maruno et al.
patent: 0 230 768 (1987-08-01), None
patent: 0 450 092 (1991-10-01), None
patent: 0450092 (1996-08-01), None
patent: WO 91 09678 (1991-07-01), None
patent: WO 96 09840 (1996-04-01), None
patent: WO 00 30657 (2000-06-01), None
Bulte et al. (Short-vs. Long-Circulating Magnetoliposomes as Bone Marrow-Seeking MR Contrast Agents, Journal of Magnetic Resonance Imaging, Feb. 1999, vol. 9, pp. 329-335).
Briseid, G., et al., “Dextran-Induced Anaphylactoid Reaction in Man: Altered Reactivity of High Molecular Weight Kininogen,”Acta Pharmcol. Et toxicol., 1980, 47:119-126.
Grimm, Jan, et al., “Characterization of Ultrasmall, Paramagnetic Magnetite Particles as Superparamagnetic Contrast Agents in MRI,” Database Chemabs [Online]:Invest. Radiol., 2000, vol. 35(9), pp. 553-556.
Hanna, C.H., et al., “Effect of Ether and Barbiturate Anesthesia on the Reaction of Rats to Dextran and of Dogs to Polyvinylpyrrolidone,”Am. J. Physiol.1957, 191:615-620.
Hasegawa, et al., “Biological Behavior of Dextran-Iron Oxide Magnetic Fluid Injected Intravenously in Rats,”Japan J. Appl. Phys., 1998, vol. 37:1029-1032.
Hedin, H., et al., “Prevention of Dextran Anaphylaxis,”Int. Arch. Allergy and Immunol., 1997:113:358-359.
Jue, C.K., et al., “Determination of Reducing Sugars in the Nanomole Range with Tetrazolium Blue,”J. Biochem. Biophys. Methods, 1985, 11:109-115.
Kitchen, R., “Total Polysaccharide Test and Quantitative Method for Dextran,”Proc. Sugar Process. Res. Conf., 1983, 232-247.
Kumar, K., “Iron Assay and Size Exclusion High Performance Liquid Chromatography of Ferritin and Magnetoferritin,”J. Liq. Chrom. Rel. Technol., 1997, 20, 3351-3364.
Squire, J.R., et al., “Dextran, Its Properties and Use in Medicine” Charles C. Thomas, Springfield, IL, 1955.
Vorhees, A.B., et al., “Reactions of Albino Rats to Injections of Dextran,”Proc. Soc. Exp. Biol. Med., 1951, 76:254.
Wooding, et al., “Proteins and Carbohydrates as Alternative Surfactants for the Preparation of Stable Magnetic Fluids,”IEEE Transactions on Magnetics, vol. 24, No. 2, Mar. 1998, pp. 1650-1652.
Bengele Howard
Frigo Timothy B.
Groman Ernest V.
Lewis Jerome M.
Paul Kenneth G.
AMAG Pharmaceuticals, Inc.
Padmanabhan Sreeni
Soroush Layla
Sunstein Kann Murphy & Timbers LLP
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