Polynucleotides, vectors, cells and an expression method for hum

Details Polynucleotides, vectors, cells and an expression method for hum Polynucleotides, vectors, cells and an expression method for hum

1995-06-06

1997-12-09

Elliott, George C.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 691, 435 701, 435 711, 4351723, 4352402, 4352523, 4353201, 536 221, 536 231, 536 235, 536 253, C12P 2104, C12N 1500, C07H 1900, C07H 2102

Patent

active

056959800

ABSTRACT:
A human hMutT2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for hydrolyzing and eliminating oxidized guanine nucleotides from the nucleotide pool to ensure correct DNA synthesis. Diagnostic assays are also disclosed which detect the presence of a mutated form of hMutT2 and over-expression of the hMutT2 protein.

REFERENCES:
PCT International Search Report.
J. of Bio. Chem., vol. 268, No. 31, pp. 23524-23530 (Nov. 5, 1993).
Proc. Natl. Acad. Sci., vol. 89, pp. 11021-11025 (Nov. 1992).
Mut. Res., vol. 299, pp. 277-287 (1993).
Mol. Gen. Genet., vol. 206, pp. 9-16 (1987).
Nature, vol. 355, pp. 273-275 (Jan. 16, 1992).
New England Biolabs Catalog, Beverly, MA, USA, p. 60, 1986
Cross et al., "Purification of CpG islands using a methylated DNA binding column", Nature Genetics, vol. 6, pp. 236-244 Mar. 1994.
Devlin "Texbook of Biochemistry with clinical correlations", A Wiley medical publication, pp. 986-987, 1982.

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