Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2007-11-20
2007-11-20
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C438S118000, C438S069000, C438S320000, C438S252000, C536S023200
Reexamination Certificate
active
11330123
ABSTRACT:
This invention provides genes and their encoded proteins, involved in the biosynthesis of farnesyl dibenzodiazepinones, including ECO-04601. The invention relates to expression vectors comprising the genes and to host cell transformed with these vectors. The invention further relates to methods of producing farnesyl dibenzodiazepinone compounds using the genes and proteins of the invention, for example, involving expression of biosynthetic pathway genes in transformed host cells.
REFERENCES:
patent: 5283173 (1994-02-01), Fields
patent: 5393665 (1995-02-01), Fayerman
patent: 5466590 (1995-11-01), Sariaslani
patent: 5541181 (1996-07-01), Ohkuma
patent: 5556772 (1996-09-01), Sorge
patent: 5830695 (1998-11-01), Serizawa
patent: 2003/0052268 (2003-03-01), Doroshenko
patent: WO-2004-065591 (2004-08-01), None
Whisstock et al. Quaterly Reviews of Biophysics, 2003, “Prediction of protein function from protein sequence and structure”, 36(3): 307-340.
Branden et al. Introduction to protein structure, Gerald Publishing Inc., New York, p. 247, 1991.
Witkowski et al. Conversion of a beta-ketoacyl synthase to a malonyl decarboxylase by replacement of the active-site cysteine with glutamine, Biochemistry. Sep. 7, 1999;38(36):11643-50.
Seffernick et al. Melamine deaminase and atrazine chlorohydrolase: 98 percent identical but functionally different, J Bacteriol. Apr. 2001;183(8):2405-10.
Carillo H. and Lipman D., Siam J. Applied Math. (1988)vol. 48, No. 5, pp. 1073-1082 “The Multiple Sequence Alignment Problem in Biology”.
Goodfellow M., Bergey's Manual of Systematic Bacteriology (1989) vol. 4, pp. 2322-2339 “Suprageneric Classification of Actinomycetes”.
Embley T. M. and Stackebrandt E., Ann. Rev. Microbiol. (1994) vol. 48, pp. 257-289 “The molecular phylogeny and systematics of the actinomycetes”.
Herlt A. J. et al., Aust. J. Chem. (1981) vol. 34, pp. 1319-1324 “Synthesis of Unlabelled and Carboxyl-Labelled 3-Amino-5-hydroxybenzoic Acid”.
Murakami T. et al., J. Bacteriol. (1989) vol. 171, No. 3, pp. 1459-1466 “Thiostrepton-Induced Gene Expression inStreptomyces lividans”.
Thompson C. J. et al., J. Bacteriol. (1982) vol. 151, No. 2, pp. 668-677 “Cloning of Antibiotic Resistance and Nutritional Genes in Streptomycetes”.
Nielson K. B. et al., Strategies (1994) vol. 7, pp. 27 “Taq Extender PCR Additive for Improved Length, Yield and Reliability of PCR Products”.
Gluzman Y., Cell (1981) vol. 23, pp. 175-182 “SV40-Transformer Simian Cells Support the Replication of Early SV40 Mutants”.
Workman P. et al., British Journal of Cancer, Second Edition (1997) vol. 77, pp. 1-10 “UKCCCR guidelines for the welfare of animals in experimental neoplasma”.
Premont J., Biochim Biophys Acta. (1975), vol. 381, pp. 368-376 “[3H] Norepinephrine binding by rat glial cells in culture lack of correlation between binding and adenylate cyclase activation”.
Zazopoulos et al., Nature Biotechnol. (2003) vol. 21, pp. 187-190 “A genomics-guided approach for discovering and expressing cryptic metabolic pathways”.
Stryer L., Biochemisty 3rd edition (1988) W.H. Freeman and Co., New York, pp. 752-754.
Altschul S. F. et al. J. Mol. Biol. (1990)vol. 215, pp. 403-410 “Basic Local Alignment Search Tool”.
Takagi M. et al., J. Bacteriol. (2000) vol. 182, No. 15, pp. 4153-4157 “A Gene Cluster for the Mevalonate Pathway from Streptomyces sp. Strain CL190”.
Birnboim H. C. and Doly J., Nucleic Acids Research (1979)vol. 7, No. 6, pp. 1513-1523 “A rapid alkaline extraction procedure for screening recombinant plasmid DNA”.
Farnet Chris M.
Zazopoulos Emmanuel
Chowdhury Iqbal
Prouty Rebecca E.
Thallion Pharmceuticals Inc.
LandOfFree
Polynucleotides for production of farnesyl dibenzodiazepinones does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polynucleotides for production of farnesyl dibenzodiazepinones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotides for production of farnesyl dibenzodiazepinones will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3841394