Polynucleotides for determining the pen polymorphism of human pl

Details Polynucleotides for determining the pen polymorphism of human pl Polynucleotides for determining the pen polymorphism of human pl

1995-06-07

1998-07-14

Ketter, James

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 2431, C12Q 168

Patent

active

057802297

ABSTRACT:
Isolated polynucleotide molecules and peptides encoded by these molecules can be used in the analysis of alloantigen phenotypes, as well as in diagnostic and therapeutic applications, relating to human platelet Pen polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from platelet mRNA, it is possible to type glycoprotein GPIIIa with regard to the Pen polymorphism, for example, in the context of diagnosing and treating clinical syndromes associated with GPIIIa-related immune responses.

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Zimrin, A.B. et al. 1990 J. Biol Chem 265(2): 8590-8585.
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Wang et al., "An Amino Acid Polymorphism within the RGD Binding Domain of Platelet Membrane Glycoprotein IIIa is Responsible for the Formation of the Pen.sup.a /Pen.sup.b . . . " J. Clin. Invest. 90: 2038-2043 (Nov. 1992).
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Derwent Abstracts for Japanese patent document No. JP2300664 and U.S. Pat. No. 5,288,610.

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