Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1999-03-23
2000-12-26
Achutamurthy, Ponnathapu
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
4353201, 4352523, 536 232, C12N 910
Patent
active
061657646
ABSTRACT:
The invention provides tRNA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing trmD polypeptides to screen for antibacterial compounds.
REFERENCES:
Gabryszuk, et al., "tRNA recognition for modification: Solution probing of tRNA complexed with Escherichia coli tRNA (gunaosine-1) methyltransferase", RNA, vol. 3, pp. 1327-1336, 1997.
Redlak, et al., "Interaction of tRNA with tRNA (Guanosine-1) methyltransferase: Binding Specificity Determinants Involve the Dinucleotide G.sup.36 pG.sup.37 and Tertiary Structure", Biochemistry, vol. 36, pp. 8699-8709, 1997.
Li, et al., "1-Methylguanosine Deficiency of tRNA Influences Cognate Codon Interaction and Metabolism in Salmonella typhimurium", Journal of Bacteriology, vol. 177,No. 22, pp. 6593-6600, Nov. 1995.
Persson, et al, "Functional Analysis of the ffh-trmD Region of the Escherichia coli Chromosome by Using Reverse Genetics", Journal of Bacteriology, vol. 177, No. 19, Oct. 1995. pp. 5554-5560.
Kunst, et al., "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis", GenBank Submission, Accession No. Z99112, Nov. 20, 1997.
Berglindh, et al., "H. pylori cytoplasmic protein, 02cp 11404orf11", GenSeqP Submission, Accession No. W20642, Jul. 14, 1997.
Bystrom, et al., "The Structural gene (trmD) for the tRNA (m.sup.1 G)Methyltransferase is part of a four polypeptide operon in Escherichia coli K-12", Mol. Gen. Genet., 1982, vol. 188, pp. 447-454.
International search report from corresponding International patent application number PCT/US99/26191.
Biswas Sanjoy
Brown James Raymond
Chalker Alison Francis
Holmes David John
Ingraham Karen Anne
Achutamurthy Ponnathapu
Deibert Thomas S.
Gimmi Edward R.
Kerr Kathleen
King William T.
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