Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2006-12-26
2006-12-26
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S320100, C435S252300, C435S252330, C435S348000, C435S419000, C435S254100, C435S254200, C435S325000, C536S023200
Reexamination Certificate
active
07153678
ABSTRACT:
The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
REFERENCES:
patent: 5849902 (1998-12-01), Arrow et al.
patent: 6664089 (2003-12-01), Meyers
patent: 2002/0034807 (2002-03-01), Meyers
patent: 2004/0009501 (2004-01-01), Curtis et al.
patent: 1 293 569 (2003-03-01), None
patent: WO9201050 (1992-01-01), None
patent: WO9706245 (1997-02-01), None
patent: WO0039751 (2000-07-01), None
patent: WO0105983 (2001-01-01), None
patent: WO0109316 (2001-02-01), None
patent: WO0109345 (2001-02-01), None
patent: WO0112819 (2001-02-01), None
patent: WO0120004 (2001-03-01), None
patent: WO0146394 (2001-06-01), None
patent: WO 01/53455 (2001-07-01), None
patent: WO0173059 (2001-10-01), None
patent: WO0175067 (2001-10-01), None
patent: WO0177340 (2001-10-01), None
patent: WO0200677 (2002-01-01), None
patent: WO0210363 (2002-02-01), None
patent: WO0220747 (2002-03-01), None
patent: WO0222660 (2002-03-01), None
patent: WO 02/31111 (2002-04-01), None
patent: WO0226997 (2002-04-01), None
patent: WO 02/057460 (2002-07-01), None
patent: WO0252005 (2002-07-01), None
patent: WO 02/068649 (2002-09-01), None
patent: WO 03/000844 (2003-01-01), None
patent: WO 03/010327 (2003-02-01), None
patent: WO 03/018812 (2003-03-01), None
patent: WO 03/072035 (2003-09-01), None
Genbank Data Base Acc#AB051487/gi: 12697944. Nagase et al Feb. 7, 2001.
Issued Patents Data Base US6,664,089 Seq ID No. 3. Meyers et al Dec. 16, 2003; priority date Feb. 24, 2000.
SPTREMBL—25 Database Masuda et al Accession No. Q920R2 Dec. 1, 2001 from J. Biol Chem 275; 39002-39011 (2001). Alignment with SEQ ID No: 109.
Johnson et al Regulation of dual-specificity phosphatases M3/6 and hVH5 by phorbol esters. Analysis of a delta-like domain J Biol Chem. Oct.13, 2000;275(41):31755-62.
Duesterhoeft et al., “Homo sapiensmRNA, cDNA DKFZp434C035 (from clone DKFZp434C035)”, Database Accession No. AL137633 XP002211554, retrieved from EBI, Accession No. HSM802399, Jan. 27, 2000.
ENSEMBL:ENSP00000204051.
Isogai et al., “Homo sapienscDNA FLJ12041 fis, clone HEMBB1001945”, Database accession No. AK022103 XP002211553, retrieved from EBI, Sep. 29, 2000.
JBC Manuscript M104600200, MKP-7, a novel MAP Kinase Phosphatase, functions as a shuttle protein, Masuda et al., Aug. 6, 2001.
Martell, K.J. et al., “hVH-5: A Protein Tyrosine Phosphatase Abundant in Brain that Inactivates Mitogen-Activated Protein Kinase”, Journal of Neurochemistry, vol. 65, No. 4, 1995, pp. 1823-1833, XP000196676.
Nagase et al. (2000) DNA Research, 7:347-355.
NCBI Entrez Accession No. gi|12654609, Strausberg, R., Jul. 12, 2001.
NCBI Entrez Accession No. gi|12697945, Nagase, T. et al., Feb. 7, 2001.
NCBI Entrez Accession No. gi|13990989, Masuda, K. et al., Oct. 18, 2001.
NCBI Entrez Accession NO gi|14728095, NCBI Annotation Project, National Center for Biotechnology, Jul. 16, 2001.
NCBI Entrez Accession NO gi|14756395, NCBI Annotation Project, National Center for Biotechnology, Aug. 1, 2002.
NCBI Entrez Accession No. gi|17402248, Johnson, C., Dec. 5, 2001.
NCBI Entrez Accession NO gi|20137933, Masuda, K. et al., Jun. 15, 2002.
NCBI Entrez Accession NO gi|21594973, Strausberg, R., Jun. 26, 2002.
NCBI Entrez Accession No. gi|22748893, Ninomiya, K. et al., Sep. 6, 2002.
NCBI Entrez Accession NO gi|8923413, Watanabe, K. et al., Feb. 10, 2002.
NCBI Entrez Accession NO gi|9280136, Hashimoto, K. et al., Oct. 11, 2001.
NCBI Entrez Accession No. gi|AK000449, Watanabe, K. et al., Feb. 22, 2000.
NCBI Entrez Accession No. gi|AK055973, Tashiro, H. et al., Aug. 1, 2002.
NCBI Entrez Accession No. gi|AL360020, Johnson, C., Dec. 5, 2001.
NCBI Entrez Accession No. gi|BAB40814, Masuda, K. et al., Oct. 18, 2001.
NCBI Entrez Accession No. gi|BAB71060, Tashiro, H. et al., Aug. 1, 2002.
NCBI Entrez Accession No. gi|BC001140, Strausberg, R., Jul. 12, 2001.
Shafer et al., “Human Immunodeficiency Virus Reverse Transcriptase and Protease Sequence Database”, Nucleic Acids Research, vol. 28, No. 1, Jan. 1, 2000, pp. 346-348, XP002202302.
Swiss-Prot Accession No: Q8WX19, Release 20, Mar. 2002.
Swiss-Prot Accession No: Q920R2, Release 19, Dec. 2001.
Swiss-Prot Accession No: Q96N49, Release, 19, Dec. 2001.
Swiss-Prot Accession No: Q9BVJ7, Release, Jun. 17, 2001.
Swiss-Prot Accession No: Q9BY84, Release 41, Jun. 2002.
Swiss-Prot Accession No: Q9N091, Release 15, Oct. 2000.
Swiss-Prot Accession No: Q9NX48, Release 15, Oct. 2000.
Swiss-Prot Accession No: Q9C0G3 (J. Biol. Chem. 276:39002-39011 (2001).
NCBI Entrez Accession No. gi|AX260340, Meyers, R.A., Oct. 26, 2001.
NCBI Entrez Accession No. gi|NP—085143, Hoornaert, I. et al., Jan. 26, 2004.
NCBI Entrez Accession No. gi|XP—059988, NCBI Annotation Project, Aug. 1, 2002.
NCBI Entrez Accession No. gi|7020545, Watanabe, K. et al., Sep. 13, 2003.
NCBI Entrez Accession No. gi|16165772, NCBI Annotation Project, May 8. 2002.
NCBI Entrez Accession. No. gi|20834581, NCBI Annotation Project, May 16, 2002.
NCBI Entrez Accession No. gi|25050344, NCBI Annotation Project, Nov. 17, 2002.
NCBI Entrez Accession No. gi|27469789, Stausberg, R.L. et al., Oct. 7, 2003.
NCBI Entrez Accession No. gi|27497737, Guo, J.H. et al., Jan. 4, 2003.
NCBI Entrez Accession No. gi|27764880, Guo, J.H. et al., Apr. 7, 2003.
NCBI Entrez Accession No. gi|30089950, Ota, T. et al., May 6, 2004.
NCBI Entrez Accession No. gi|30089952, Ota, T. et al., May 6, 2004.
NCBI Entrez Accession No. gi|34880952, Oct. 23, 2002.
NCBI Entrez Accession No. gi|45501280, Strausberg, R.L. et al., May 10, 2004.
Hoornaert, I. et al., “MAPK phosphatase DUSP 16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation”, Oncogene, vol. 22, pp. 7728-7736 (2003).
Mammalian Gene Collection (MGC) Program Team, “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”, Proc. Natl. Acad Sci. USA, vol. 99, No. 26, pp. 16899-16903 (2002).
Ota, T. et al., “Complete sequencing and characterization of 21,243 full-length human cDNAs”, Nature Genetics, vol. 36, No. 1, pp. 40-45 (2004).
Saha, S. et al., “A Phosphatase Associated with Metastasis of Colorectal Cancer”, Science, vol. 294, pp. 1343-1346 (2001).
Altschul, et al., “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs”, Nucleic Acids Res., vol. 25(17), pp. 3389-3402 (1997).
Altschul, et al., “Basic Local Alignment Search Tool”, J. Mol. Biol., vol. 215, pp. 403-410 (1990).
Arlin, et al., “Eukaryotic methionyl aminopeptidases: Two classes of cobalt-dependent enzymes”, PNAS, vol. 92, pp. 7714-7718 (1995).
Bateman, et al., “The Pfam Protein Families Database”, Nucleic Acids Res., vol. 28(1), pp. 263-266 (2000).
Bazan, et al., “Sequence and structure comparison suggest that methionine aminopeptidase prolidase, aminopeptidase P, and creatinase share a common fold”, PNAS, vol. 91, pp. 2473-2477 (1994).
Bernstein, et al., “The Protein Data Bank: A computer-based Archival File for Macromolecular Structures”, J. Mol. Biol., vol. 112, pp. 535-542 (1977).
Böhm, HJ., “The computer program LUDI: A new method for the de novo design of enzyme inhibitors”, J. Computer Aided Mol. Design, vol. 6, pp. 61-78 (1992).
Bradshaw, et al., “N-Terminal processing: the methionine aminopeptidase and Nα-acetyl transferase famili
Banas Dana
Feder John N.
Finger Joshua
Jackson Donald G.
Lee Liana
Bristol-Myers Squibb
D'Amico Stephen C.
Prouty Rebecca E.
LandOfFree
Polynucleotides encoding the novel human phosphatase, RET31,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polynucleotides encoding the novel human phosphatase, RET31,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotides encoding the novel human phosphatase, RET31,... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3714937