Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-05-03
2011-05-03
Carlson, Karen Cochrane (Department: 1652)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S195000, C435S069100, C435S252300, C570S101000
Reexamination Certificate
active
07935803
ABSTRACT:
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.
REFERENCES:
patent: 3131122 (1964-04-01), Freter
patent: 4574079 (1986-03-01), Gavras et al.
patent: 4818807 (1989-04-01), Morita et al.
patent: 5071469 (1991-12-01), Artz
patent: 5099020 (1992-03-01), Grote et al.
patent: 5110833 (1992-05-01), Mosbach
patent: 5128247 (1992-07-01), Koller
patent: 5372944 (1994-12-01), Swanson
patent: 5476770 (1995-12-01), Pradelles
patent: 5503977 (1996-04-01), Johnsson et al.
patent: 5523209 (1996-06-01), Ginsberg et al.
patent: 5576424 (1996-11-01), Mao et al.
patent: 5700908 (1997-12-01), Ruoslahti et al.
patent: 5700935 (1997-12-01), Takenishi et al.
patent: 5786428 (1998-07-01), Arnold et al.
patent: 5821047 (1998-10-01), Garrard et al.
patent: 5932421 (1999-08-01), Ginsberg et al.
patent: 5945526 (1999-08-01), Lee et al.
patent: 6255461 (2001-07-01), Mosbach et al.
patent: 6333154 (2001-12-01), Ladant et al.
patent: 6416733 (2002-07-01), Barrett et al.
patent: 6492560 (2002-12-01), Wilbur et al.
patent: 6537776 (2003-03-01), Short
patent: 6800453 (2004-10-01), Labaer et al.
patent: 7078504 (2006-07-01), Short et al.
patent: 7238842 (2007-07-01), Wood et al.
patent: 7425436 (2008-09-01), Darzins et al.
patent: 7429472 (2008-09-01), Darzins et al.
patent: 2002/0042055 (2002-04-01), Affholter
patent: 2002/0137171 (2002-09-01), Short et al.
patent: 2003/0166957 (2003-09-01), Benneteau et al.
patent: 2004/0152880 (2004-08-01), Minden
patent: 2004/0214258 (2004-10-01), Wood et al.
patent: 2005/0048580 (2005-03-01), Labaer et al.
patent: 2005/0095651 (2005-05-01), Camarero et al.
patent: 2005/0272114 (2005-12-01), Darzins et al.
patent: 2006/0024808 (2006-02-01), Darzins et al.
patent: 2007/0087400 (2007-04-01), Darzins et al.
patent: 2007/0224620 (2007-09-01), Hartzell et al.
patent: 2008/0026407 (2008-01-01), Wood et al.
patent: 2008/0145882 (2008-06-01), Darzins et al.
patent: 2009/0098627 (2009-04-01), Darzins et al.
patent: 616 245 (1962-10-01), None
patent: 616245 (1962-10-01), None
patent: 259396 (1988-10-01), None
patent: 718300 (1996-06-01), None
patent: WO-98/36080 (1998-08-01), None
patent: WO-01/53303 (2001-07-01), None
patent: WO-0160415 (2001-08-01), None
patent: WO-0177668 (2001-10-01), None
patent: WO-02/28841 (2002-04-01), None
patent: WO-02057411 (2002-07-01), None
patent: WO-02068583 (2002-09-01), None
patent: WO-02/083937 (2002-10-01), None
patent: WO-03040096 (2003-05-01), None
patent: WO-2004009788 (2004-01-01), None
patent: WO-2004072232 (2004-08-01), None
patent: WO-2006093529 (2006-09-01), None
patent: WO-2006093529 (2006-09-01), None
patent: WO-2007092579 (2007-08-01), None
patent: 2008/054821 (2008-05-01), None
Instant Notes—Chemistry for Biologists, (Second Edition), Garland Science/BIOS Scientific Publishers, (2004), 245-246.
“U.S. Appl. No. 11/006,031, Notice of Allowance mailed Apr. 24, 2008”, 4 pgs.
“U.S. Appl. No. 11/509,796, Restriction Requirement mailed Mar. 28, 2008”, 14 pgs.
“U.S. Appl. No. 11/509,796, Non-Final Office Action mailed Nov. 12, 2008”, 22 pgs.
“U.S. Appl. No. 11/509,796, Notice of Non-Responsive Amendment mailed Jun. 30, 2008”, 6 pgs.
“U.S. Appl. No. 11/509,796, Response filed Jul. 30, 2008 to Notice of Non-Responsive Amendment mailed Jun. 30, 2008”, 10 pgs.
“U.S. Appl. No. 11/509,796, Response to Restriction Requirement and Preliminary Amendment filed Apr. 28, 2008 to Restriction Requirement mailed Mar. 28, 2008.”, 12 pgs.
“U.S. Appl. No. 11/704,150, Restriction Requirement mailed Mar. 30, 2009”, 11 pgs.
“U.S. Appl. No. 11/704,150, Non-Final Office Action mailed Sep. 8, 2009”, 12 pgs.
“U.S. Appl. No. 11/704,150, Response filed May 6, 2009 to Restriction Requirement mailed Mar. 30, 2009”, 12 pgs.
“U.S. Appl. No. 11/786,792, Non-Final Office Action mailed Feb. 5, 2009”, 10 pgs.
“U.S. Appl. No. 11/786,792, Response filed Dec. 23, 2008 to Restriction Requirement mailed Nov. 26, 2008”, 15 pgs.
“U.S. Appl. No. 11/786,792, Final Office Action mailed Jul. 10, 2009”, 14 pgs.
“U.S. Appl. No. 11/786,792, Response filed Jun. 2, 2009 to Non Final Office Action mailed Feb. 5, 2009”, 16 pgs.
“U.S. Appl. No. 12/220,478, Preliminary Amendment filed Dec. 2, 2008”, 3 pgs.
“U.S. Appl. No. 12/284,010, Preliminary Amendment filed Aug. 17, 2008”, 18 pgs.
“U.S. Appl. No. 12/284,010, Non-Final Office Action mailed Mar. 23, 2009”, 15 pgs.
“U.S. No. 12/284,010, Response filed Jul. 10, 2009 to Non Final Office Action mailed Mar. 23, 2009”, 17 pgs.
“Australian Application Serial No. 2004211584, First Examiner Report mailed Jan. 6, 2009”, 3 pgs.
“Australian Application Serial No. 2004211584, Response filed Sep. 9, 2009 to First Examiner Report mailed Jan. 6, 2009”, 28 pgs.
“Chinese Application Serial No. 200480008194.4, Response filed to Second Office Action mailed May 22, 2009”, (2009), 14 pgs.
“Chinese Application Serial No. 200480008194.4, Second Office Action mailed May 22, 2009” 15 pgs.
“European Application Serial No. 04707032.1, Communication mailed Jun. 22, 2009”, 6 pgs.
“European Application Serial No. 05857556.4, Communication mailed May 7, 2009”, 3 pgs.
“European Application Serial No. 07763411.1, Office Action mailed Dec. 17, 2008”, 2 pgs.
“European Application Serial No. 07763411.1, Office Action mailed Mar. 17, 2009”, 5 pgs.
“Indian Application Serial No. 3867/DELNP/2005, First Examination Report dated Sep. 28, 2007”, 19 pgs.
“Indian Application Serial No. 3867/DELNP/2005, Response filed Mar. 19, 2008 to First Examination Report dated Sep. 28, 2007”, 21 pgs.
“Indian Application Serial No. 3867/DELNP/2005, Response filed Sep. 23, 2008 to Examination Report Sep. 9, 2008”, 5 pgs.
Cheuk, K. L, et al., “Synthesis of optically active poly (phenylacetylenes) containing amino acid pendant groups”,Polymeric materials science and engineering, 82, (2000), 56-57.
Henze, H. R., et al., “The number of structurally isomeric alcohols of the methanol series”,Journal of the American Chemical Society, 53, (1931), 3042-3046.
“Valence,” Hawley's Condensed Chemical Dictionary (14th Edition) Online, John Wiley and Sons, 2002, http://www.knovel.com/knovel2/Toc.jsp?BookID=704&VerticlID=0 (Mar. 20, 2007).
Adamczyk, M. et al., “Surface plasmon resonance (SPR) as a tool for antibody conjugate analysis,” Bioconjug. Chem. (1999) 10(6):1032-1037.
Banas, P. et al., “Mechanism of enhanced conversion of 1,2,3-trichloropropane by mutant haloalkane dehalogenase revealed by molecular modeling,” J. Computer-Aided Molecular Design (2006) 20(6):375-383.
Broom, W.J. et al., “Two approaches to drug discovery in SOD1-mediated ALS,” J. Biomol. Screen (2006) 11 (7):729-735.
Chan, K. et al., “Microarray-based detection ofSalmonella enterica serovar typhimuriumtransposon mutants that cannot survive in macrophages and mice,” Infect. Immun. (2005) 73(9):5438-5449.
Dodson, G. et al., “Catalytic triads and their relatives,” Trends Biochem. Sci. (1998) 23(9):347-352.
Gao, X. et al., “Construction of murine phage antibody library and selection of ricin-specific single-chain antibodies,
Darzins Aldis
Encell Lance
Klaubert Dieter
Los Georgyi V.
McDougall Mark
Carlson Karen Cochrane
Casimir Jones S.C.
Kosson Rosanne
Promega Corporation
LandOfFree
Polynucleotides encoding proteins for covalent tethering to... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polynucleotides encoding proteins for covalent tethering to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotides encoding proteins for covalent tethering to... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2656465