Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2004-06-23
2008-10-14
Kemmerer, Elizabeth C. (Department: 1646)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069100, C435S069700, C435S070100, C435S252300, C435S254200, C435S320100, C435S348000, C435S361000, C435S365000, C435S369000, C435S371000, C435S419000, C435S455000, C435S471000, C530S350000, C536S023400
Reexamination Certificate
active
07435808
ABSTRACT:
The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
REFERENCES:
patent: 5116964 (1992-05-01), Capon et al.
patent: 5869330 (1999-02-01), Scherer et al.
patent: 9401548 (1994-01-01), None
patent: WO02/098898 (2002-12-01), None
patent: WO2004/087874 (2004-10-01), None
patent: WO2004/101618 (2004-11-01), None
Locus BQ439997, NCBI Entrez Nucleotide Database, published May 24, 2002.
Kadowaki, 2005. Endocrine Reviews. 26(3): 439-451.
Wells (Sep. 18, 1990) “Additivity of Mutational Effects in Proteins.” Biochemistry 29(37): 8509-8517.
Ngo et al. (Mar. 2, 1995) “The Protein Folding Problem and Tertiary Structure Prediction, Chapter 14: Computational Complexity Protein Structure Prediction, and the Levinthal Paradox” pp. 492-495.
Bork (2000) “Powers and Pitfalls in Sequence Analysis: The 70% Hurdle.” Genome Research 10:398-400.
Skolnick and Fetrow (2000) “From gene to protein structure and function: novel applications of computational approaches in the genomic era.” Trends in Biotech. 18(1): 34-49.
Doerks et al. (Jun. 1998) “Protein annotation: detective work for function prediction.” Trends in Genetics 14(6): 248-250.
Smith and Zhang (Nov. 1997) “The challenges of genome sequence annotation or ‘The devil is in the details’.” Nature Biotechnology 15: 1222-1223.
Brenner (Apr. 1999) “Errors in genome annotation.” Trends in Genetics 15(4): 132-133.
Borks and Bairoch (Oct. 1996) “Go hunting in sequence databases but watch out for the traps.” Trends in Genetics 12(10): 425-427.
Altschul, et al., “Basic Local Alignment Search Tool”, J. Mol. Biol., vol. 214, pp. 403-410 (1990).
Barger, et al., “p 38 Mitogen-activated Protein Kinase Activates Peroxisome Proliferator-activated Receptor α”, J. Biol. Chem., vol. 276(48), pp. 44495-44501 (2001).
Berner, et al., “Adiponectin and its receptors are expressed in bone-forming cells”, Bone, vol. 35, pp. 842-849 (2004).
Beylot, et al, “Expression of the adiponectin receptors AdipoR1 and AdipoR2 in lean rats and in obese Zucker rats”, Metabolism Clin. Exper., vol. 55, pp. 396-401 (2006).
Bluüher, et al., “Regulation of adiponectin receptor R1 and R2 gene experession in adipocytes of C57BL/6 mice”, Biochem. Biophys. Res. Comm., vol. 329, pp. 1127-1132 (2005).
Blackshaw, et al., “Genomic Analysis of Mouse Retinal Development”, PloS Biol., vol. 2(9) e247, pp. 1411-1431 (2004).
Broedl, et al., “Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome”, Cardio. Diabetology, vol. 5(11), pp. 1-7 (2006).
Carninci, et al., “High-Efficiency Full-Length cDNA Cloning”, Meth. Enzymology, vol. 303, pp. 19-44 (1999).
Carninci, et al., “Normalization and Subtraction of Cap-Trapper-Selected cDNAs to Prepare Full-Length cDNA Libraries for Rapid Discovery of New Genes”, vol. 10, pp. 1617-1630 (2000).
Cheng, et al., “Identification of Acyl Coenzyme A:Monoacylglycerol Acyltransferase 3, an Intestinal Specific Enzyme Implicated in Dietary Fat Absorption”, J. Biol. Chem., vol. 278(16), pp. 13611-13614 (2003).
Cheng, et al., “Human acyl-CoA: diacylglycerol acyltransferase is a tetrameric protein”, Biochem. J., vol. 359, pp. 707-714 (2001).
Civitarese, et al., “Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes”, Diabetologia, vol. 47, pp. 816-820 (2004).
Dieudonne, et al., “Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells”, Biochem. Biophys. Res. Comm., vol. 345, pp. 271-279 (2006).
Diez, et al., “The role of the novel adipocyte-derived hormone adiponectin in human disease”, Eur. J. Endocrin, vol. 148, pp. 293-300 (2003).
Ding, et al., “Cloning and expression of porcine adiponectin and adiponectin receptor 1 and 2 genes in pigs”, J. Anim. Sci., vol. 82, pp. 3162-3174 (2004).
Fang, et al., “Hyperglycemia- and hyperinsulinemia-induced alteration of adiponcetin receptor expression and adiponectin effects in L6 myoblasts”, J. Molec. Endocrin., vol. 35, pp. 465-476 (2005).
The Fantom Consortium, et al., “The Transcriptional Landscape of the Mammalian Genome”, Science, vol. 309, pp. 1559-1563 (2005).
The Fantom Consortium and the Riken Genome Exploration Research Group Phase 1 & II Team, Nature, vol. 420, pp. 563-573 (2002).
Fasshauer, et al., “Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes”, FEBS Ltrs., vol. 28035, pp. 27-32 (2004).
Fruebis, et al., “Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice”, PNAS, vol. 98(4), pp. 2005-2010 (2001).
Fry, et al., “Area Postrema Neurons are Modulated by the Adipocyte Hormone Adiponcetin”, J. Neurosci., vol. 26(38), pp. 9695-9702 (2006).
Fujimoto, et al., “Adiponectin is expressed in the brown adipose tissue and surrounding immature tissues in mouse embryos”, Biochim. Biophysics Acta, vol. 1731, pp. 1-12 (2005).
Fujioka, et al., “Role of adiponectin receptors in endothelin-induced cellular hypertrophy in cultured cardiomyocytes and their expression in infarcted heart”, Am. J. Physiol. Heart Circ. Physiol., vol. 290, pp. 2409-2416 (2006).
Inukai, et al., “Regulation of adiponectin receptor gene expression in diabetic mice”, Am. J. Physiol. Endocrinol. Metab., vol. 288, pp. 876-882 (2005).
Kim, et al., “Increased adiponectin receptor-1 expression in adipose tissue of impaired glucose-tolerant obese subjects during weight loss”, Eur. J. Endocrin., vol. 155, pp. 161-165 (2006).
Kubota, et al., “Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation”, J. Biol. Chem., vol. 277(29), pp. 25863-25866 (2002).
Kyte, et al., “A Simple Method for Displaying the Hydropathic Character of a Protein”, J. Mol. Biol., vol. 157, pp. 105-132 (1982).
Lord, et al., “Expression of adiponectin and its receptors in swine”, J. Anim. Sci., vol. 83, pp. 565-578 (2005).
Mammalian Gene Collection Program Team, “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”, PNAS, vol. 99(26), pp. 16899-16903 (2002).
Maeda, et al., “Diet-induced insulin resistance in mice lacking adiponectin/ACRP30”, Nature Med., vol. 8(7), pp. 731-737 (2002).
Mao, et al., “APPL1 binds to adiponectin receptors and mediates adiponectin signaling and function”, Nature Cell Biol., vol. 8(5), pp. 516-523 (Supp. Figs. 1-4) (2006).
Michael, et al., “Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1”
Cheng Dong
Lee Ning
Wu Shujian
Bristol--Myers Squibb Company
D'Amico Stephen C.
Howard Zachary C.
Kemmerer Elizabeth C.
LandOfFree
Polynucleotides encoding novel adiponectin receptor variant,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polynucleotides encoding novel adiponectin receptor variant,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotides encoding novel adiponectin receptor variant,... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3993574