Chemistry: molecular biology and microbiology – Vector – per se
Patent
1998-04-21
2000-10-31
Bansal, Geetha P.
Chemistry: molecular biology and microbiology
Vector, per se
536 231, 536 234, 536 235, 536 2353, 536 242, 4353201, 435325, 4352523, 4352542, C12N 1563, C12N 1509, C12N 510, C12N 1566, C07H 2100
Patent
active
061401137
ABSTRACT:
Polynucleotides encode soluble, multivalent molecular complexes which modify immune responses, and host cells comprise such polynucleotides. The molecular complexes comprise extracellular domains of transmembrane heterodimeric proteins, particularly T cell receptor and major histocompatibility complex proteins, which are covalently linked to the heavy and light chains of immunoglobulin molecules to provide soluble multivalent molecular complexes with high affinity for their cognate ligands. The molecular complexes can be used, inter alia, to detect and regulate antigen-specific T cells and as therapeutic agents for treating disorders involving immune system regulation, such as allergies, autoimmune diseases, tumors, infections, and transplant rejection.
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Hamad Abdel
Lebowitz Michael S.
O'Herrin Sean
Schneck Jonathan
Bansal Geetha P.
The Johns Hopkins University
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