Polynucleotides encoding interleukin-19

Details Polynucleotides encoding interleukin-19 Polynucleotides encoding interleukin-19

1997-08-29

1999-11-16

Mertz, Prema

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 712, 4353201, 435325, 4352523, 435471, 536 231, 536 235, 536 243, 536 2431, 530351, C12N 1524, C12N 1564, C12N 510, C07K 1454

Patent

active

059856149

ABSTRACT:
The present invention concerns a novel human cytokine. In particular, isolated nucleic acid molecules are provided encoding interleukin-19 (IL-19). IL-19 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further concerns therapeutic methods for modulating cytokine production.

REFERENCES:
Hellyer et al. Gene, vol. 165, pp. 279-284, 1995.
Harlow et al. Antibodies a Laboratory Manual Chap. 5, p. 76, Cold Spring Harbor Laboratory, 1988.
Cunningham et al. Science, vol. 244, pp. 1081-1085, 1989.
George et al. Macromolecules Sequencing & Synthesis Chpt. 12, pp. 127-149, Alan R. Liss, Inc. New York, 1988.
Baer, R. et al., "DNA sequence and expression of the B95-8 Epstein-Barr virus genome," Nature 310:207-211 (1984).
Benjamin, D. et al., "Human B-Cell Interleukin-10: B-Cell Lines Derived From Patients With Acquired Immunodeficiency Syndrome and Burkitts's Lymphoma Constitutively Secrete Large Quantities of Interleukin-10," Blood 80(5):1289-1298 (1992).
de Waal Malefyt, R. et al., "Interleukin 10 (IL-10) and Viral IL-10 Strongly Reduce Antigen-specific Human T Cell Proliferation by Diminishing the Antigen-presenting Capacity of Monocytes via Downregulation of Class II Major Histocompatibility Complex Expression," J. Exp. Med. 174(4):915-924 (1991).
de Waal Malefyt, R. et al., "Interleukin 10 (IL-10) Inhibits Cytokine Synthesis by Human Monocytes: An Autoregulatory Role of IL-10 Produced by Monocytes," J. Exp. Med. 174(5):1209-1220 (1991).
Feng, L. et al., "Molecular Cloning of Rat Cytokine Synthesis Inhibitory Factor (IL-10) cDNA and Expression in Spleen and Macrophages," Biochem. Biophys. Res. Commun. 192(2):452-458 (1993).
Fiorentino, D.F. et al., "Two Types of Mouse T Helper Cell, IV. Th2 Clones Secrete a Factor that Inhibits Cytokine Production by Th1 Clones," J. Exp. Med. 170:2081-2095 (1989).
Fiorentino, D.F. et al., "IL-10 Inhibits Cytokine Production by Activated Macrophages," J. Immunol. 147(11):3815-3822 (1991).
Hash, S.M. et al., "Characterization of a cDNA encoding bovine interleukin 10: kinetics of expression in bovine lymphocytes," Gene 139:257-261 (1994).
Hayakawa, K. and R.R. Hardy, "Normal, Autoimmune, and Malignant CD5+ B Cells: The Ly-1 B Lineage?" Ann. Rev. Immunol. 6:197-218 (1988).
Hisatsune, T. et al., "A Suppressive Lymphokine Derived from T.sub.S Clone 13G2 Is IL-10," Lymphokine Cytokine Res. 11(2):87-93 (1992).
Ishida, H. et al., "Continuous Anti-Interleukin 10 Antibody Administration Depletes Mice of Ly-1 B Cells but Not Conventional B Cells," J. Exp. Med. 175(5):1213-1220 (1992).
Lin, T.-Z. et al., "Cytokines in NZB CD5+ B Clones," Ann. N.Y. Acad. Sci. 651:581-583 (1992).
MacNeil, I.A. et al., "IL-10, a Novel Growth Cofactor for Mature and Immature T Cells," J. Immunol. 145(12):4167-4173 (1990).
Moore, K.W. et al., "Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI," Science 248:1230-1234 (1990).
Moore, K.W. et al., Science 250:494 (1990). Erratum to Moore, K.W. et al., "Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI," Science 248:1230-1234 (1990).
O'Garra, A. et al., "Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10," Int. Immunol. 2(9):821-832 (1990).
Ralph, P. et al., "IL-10, Lymphocyte Inhibitor of Human Blood Cell Production of Il-1 and Tumor Necrosis Factor," J. Immunol. 148(3):808-814 (1992).
Salgame, P. et al., "Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones," Science 254:279-282 (1991).
Suda, T. et al., "Identification of a Novel Thymocyte Growth-Promoting Factor Derived from B Cell Lymphomas," Cell Immunol. 129:228-240 (1990).
Tartaglia, L.A. et al., "Identification and Expression Cloning of a Leptin Receptor, OB-R," Cell 83:1263-1271 (Dec. 1995).
Vieira, P. et al., "Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Bar virus open readng frame BCRFI," Proc. Natl. Acad. Sci. USA 88:1172-1176 (1991).
Wang, S.C. et al., "FK 506, Rapamycin, and Cyclosporine: Effects on IL-4 and IL-10 mRNA Levels in a T-Helper 2 Cell Line," Transplantation Proc. 23(6):2920-2922 (1991).
Yamamura, M. et al., "Defining Protective Responses to Pathogens: Cytokine Profiles in Leprosy Lesions," Science 254:277-279 (1991).
Yssel, H. et al., "IL-10 Is Produced by Subsets of Human CD4+ T Cell Clones and Peripheral Blood T Cells," J. Immunol. 149(7):2378-2384 (1992).
International Search Report for Application No. PCT/US96/14355, mailed Dec. 1996.
NCBI Entrez, GenBank Report, Accession No. AA151733, from Hillier, L. et al. (Dec. 1996).
NCBI Entrez, GenBank Report, Accession No. AA151652, from Hillier, L. et al. (Dec. 1996).
NCBI Entrez, GenBank Report, Accession No. AA151656, from Hillier, L. et al. (May 1997).
NCBI Entrez, GenBank Report, Accession No. AA151736, from Hillier, L. et al. (May 1997).

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