Polynucleotides encoding human SLAP-2 variant, hSLAP-2v3

Details Polynucleotides encoding human SLAP-2 variant, hSLAP-2v3 Polynucleotides encoding human SLAP-2 variant, hSLAP-2v3

2007-04-24

2010-10-12

Steadman, David J (Department: 1656)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S325000, C435S252300, C435S254110, C536S023100, C536S023400, C536S023500, C536S024300, C536S024310

Reexamination Certificate

active

07811787

ABSTRACT:
The invention relates to the identification and cloning of a two novel full-length human SLAP-2 variants and their encoded polypeptides, hSLAP-2v3 and hSLAP-2v4. hSLAP-2v3 and hSLAP-2v4 are members of the SLAP family of adapter proteins and are involved in the negative regulation of intracellular T-cell signal transduction. The invention further relates to the use of these novel hSLAP-2v3 and hSLAP-2v4 polynucleotides and their encoded polypeptides as targets for therapeutic intervention in immunological and inflammatory disorders, autoimmune diseases, pulmonary diseases, proliferative immune disorders, and cancer.

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