Polynucleotides encoding human histone deacetylase HDAC9c

Details Polynucleotides encoding human histone deacetylase HDAC9c Polynucleotides encoding human histone deacetylase HDAC9c

2007-04-03

2007-04-03

Siew, Jeffrey (Department: 1642)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023200, C435S320100, C530S350000

Reexamination Certificate

active

10172094

ABSTRACT:
The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.

REFERENCES:
patent: 4218478 (1980-08-01), Omura et al.
patent: 6068987 (2000-05-01), Dulski et al.
patent: 6110697 (2000-08-01), Dulski et al.
patent: 6600351 (2003-07-01), Bisanti et al.
patent: 2003/0129724 (2003-07-01), Grozinger et al.
patent: 1394274 (2004-03-01), None
patent: WO95/11994 (1995-05-01), None
patent: WO95/25116 (1995-09-01), None
patent: WO02/102984 (2002-12-01), None
patent: WO03/029451 (2003-04-01), None
patent: WO03/065006 (2003-08-01), None
patent: WO03/068268 (2003-08-01), None
patent: WO03/087768 (2003-10-01), None
patent: WO2004/005513 (2004-01-01), None
patent: WO2004/094591 (2004-11-01), None
Ruijter et al (Biochem J, 2003, 370:737-749).
Hirashima (Int. Arch. Allergy Immunol., 2000, Suppl 1:6-9).
Benedict et al (J. Exp. Medicine, 2001, 193(1)89-99).
Jiang et al (JBC, 2003, 278(7) 4763-4769).
Bowie et al (Science, 1990, 247:1306-1310).
Boehringer Mannheim Biochemicals, 1994 Catalog, p. 93.
NCBI Entrez Accession No. gi|12733405, NCBI Annotation Project, Oct. 16, 2001.
NCBI Entrez Accession No. gi|13183017, Zhou, X. et al., Mar. 2, 2001.
NCBI Entrez Accession No. gi|15590680, Zhou, X. et al., Sep. 12, 2001.
NCBI Entrez Accession No. gi|15590682, Zhou, X. et al., Sep. 12, 2001.
NCBI Entrez Accession No. gi|16162463, NCBI Annotation Project, Oct. 16, 2001.
NCBI Entrez Accession No. gi|16162465, NCBI Annotation Project, Oct. 16, 2001.
NCBI Entrez Accession No. gi|17158039, Sparrow, D.B. et al., Nov. 5, 2002.
NCBI Entrez Accession No. gi|17158041, Sparrow, D.B. et al., Nov. 5, 2002.
NCBI Entrez Accession No. gi|18202676, Zhou, X. et al., Oct. 16, 2001.
NCBI Entrez Accession No. gi|19865267, Zhou, X. et al., Jun. 15, 2002.
NCBI Entrez Accession No. gi|21756856, Tanigami, A. et al., Jul. 15, 2002.
NCBI Entrez Accession No. gi|3882209, Nagase, T. et al., Jun. 16, 1999.
NCBI Entrez Accession No. gi|7662280, Sparrow, D.B. et al., Nov. 5, 2002.
Mahlknecht, U. et al., “Chromosomal organization and localization of the human histone deacetylase 9 gene (HDAC9)”, Biochemical and Biophysical Research Communications 293, pp. 182-191 (2002).
Marks, P.A. et al., “Histone Deacetylase Inhibitors: Inducers of Differentation or Apoptosis of Transformed Cells”, Journal of the National Cancer Institute, vol. 92, No. 15, pp. 1210-1216 (2000).
Nagase, T. et al., “Prediction of the Coding Sequences of Unidentified Human Genes. XI. The Complete Sequences of 100 New cDNA Clones from Brain Which Code for Large Proteinsin vitro”, DNA Research 5, pp. 277-286 (1998).
Sparrow, D.B. et al., “MEF-2 function is modified by a novel co-repressor, MITR”, The EMBO Journal, vol. 18, No. 18, pp. 5085-5098 (1999).
Wang, A.H. et al., “HDAC4, a Human Histone Deacetylase Related to Yeast HDA1, Is a Transcriptional Corepressor”, Molecular and Cellular Biology, vol. 19, No. 11, pp. 7816-7827 (1999).
Zhang, C.L. et al., “Association of COOH-terminal-binding Protein (CtBP) and MEF2-interacting Transcription Repressor (MITR) Contributes to Transcriptional Repression of the MEF2 Transcription Factor”, The Journal of Biological Chemistry, vol. 276, No. 1, pp. 35-39 (2001).
Zhou, X. et al., “Cloning and characterization of a histone deacetylase, HDAC9”, Proc. Natl. Acad. Sci. U.S.A., vol. 98, No. 19, pp. 10572-10577 (2001).
NCBI Entrez Accession No. AF124924 (gi:6119845), Wang, et al., Oct. 27, 1999.
The Sanger Center, “Toward a Complete Human Genome Sequence”, Genome Res., vol. 8, pp. 1097-1108 (1998).
Altschul, Stephen F., “A Protein Alignment Scoring System Sensitive at All Evolutionary Distances”, J. Mol. Evol., vol. 36, pp. 290-300 (1993).
Altschul, et al., “Gapped Blast and PSI-Blast: a new generation of protein database search programs”, Nucleic Acids Res., vol. 25(17), pp. 3389-3402 (1997).
Bateman, et al., “The Pfam Protein Families Database”, Nucleic Acids Res., vol. 30(1), pp. 276-280 (2002).
Bateman, et al., “Pfam 3.1:1313 multiple alignments and profile HMMs match the majority of proteins”, Nucleic Acids Res., vol. 27(1), pp. 260-262 (1999).
Birney, et al., “Using GeneWise in theDrosophilaAnnotation Experiment”, Genome Res., vol. 10, pp. 547-548 (2000).
Bolton, et al., “The Labelling of Proteins to High Specific Radioactivities by Conjugation to a123I-Containing Acylation Agent”, Biochem. J., vol. 133, pp. 529-539 (1973).
Burge, et al., “Prediction of Complete Gene Structures in Human Genomic DNA”, J. Mol. Biol., vol. 268, pp. 78-94 (1997).
Butler, et al., “Inhibition of Transformed Cell Growth and Induction of Cellular Differentiation by Pyroxamide, an Inhibitor of Histone Deacetylase”, Clin. Cancer Res., vol. 7, pp. 962-970 (2001).
Coffey, et al., “The Histone Deacetylase Inhibitor, CBHA, Inhibits Growth of Human Neuroblastoma Xenograftsin Vivo, Alone and Synergistically withAll-TransRetinoic Acid”, Cancer Res., vol. 61, pp. 3591-3594 (2001).
Cress, et al., “Histone Deacetylases, Transcriptional Control, and Cancer”, J. Cell. Physiol., vol. 184, pp. 1-16 (2000).
David, et al., “Molecular characterization of a familial translocation implicates disruption ofHDAC9and possible position effect onTGFβ2in the pathogenesis of Peters' anomaly”, Genomics, vol. 81, pp. 489-503 (2003).
Finnin, et al., “Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors”, Nature, vol. 401, pp. 188-193 (1999).
Florea, et al., “A Computer Program for Aligning a cDNA Sequence with a Genomic DNA Sequence”, Genome Res., vol. 8, pp. 967-974 (1998).
Gray, et al., “The Human Histone Deacetylase Family”, Experimental Cell Res., vol. 262, pp. 75-83 (2001).
Grozinger, et al., “Three proteins define a class of human histone deacetylases related to yeast Hda1p”, PNAS, vol. 96, pp. 4868-4873 (1999).
Han, et al., “Mechanism of Recruitment of Class II Histone Deacetylases by Myocyte Enhancer Factor-2”, J. Mol. Biol., vol. 345, pp. 91-102 (2005).
Henderson, et al., “Lymphoid Enhancer Factor-1 Blocks Adenomatous Polyposis Coli-mediated Nuclear Export and Degregation of β-Catenin”, J. Biol. Chem., vol. 277 (27), pp. 24258-24264 (2002).
Higgins, et al., “Using Clustal for Multiple Sequence Alignments”, Methods Enzymol., vol. 266, pp. 383-402 (1996).
Hillier, et al., “The DNA sequence of human chromosome 7”, Nature, vol. 424, pp. 157-164 (2003).
Hofmann, et al., The Prosite database, its status in 1999, Nucleic Acids Res., vol. 27 (1), pp. 215-219 (1999).
Huang, et al., “Suberoylanilide Hydroxamic Acid as a Potential Therapeutic Agent for Human Breast Cancer Treatment”, Mol. Medicine, vol. 6 (10), pp. 849-866 (2000).
Khochbin, et al., “Functional significance of histone deacetylase diversity”, Curr. Opin. Genetics Develop., vol. 11, pp. 162-166 (2001).
King, et al., “Amplification of a Novel v-erbB-Related Gene in a Human Mammary

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