Polynucleotides encoding human endokine alpha

Details Polynucleotides encoding human endokine alpha Polynucleotides encoding human endokine alpha

1997-08-15

1999-12-07

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 4352523, 4353201, 536 235, 536 243, C12N 1528, C12N 1500

Patent

active

059981717

ABSTRACT:
The present invention novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.

REFERENCES:
patent: 5288852 (1994-02-01), Yamada et al.
Aggarwal, B.B. and K. Natarajan, "Tumor necrosis factors: Developments during the last decade," Eur. Cytokine Netw. 7(2):93-124 (Apr.-Jun. 1996).
Beutler, B. et al., "Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin," Science 229:869-871 (1985).
Bringman, T.S. and B.B. Aggarwal, "Monoclonal Antibodies to Human Tumor Necrosis Factors Alpha and Beta: Application for Affinity Purification, Immunoassays, and as Structural Probes," Hybridoma 6(5):489-507 (1987).
Elliott, M.J. and R.N. Maini, "Anti-cytokine therapy in rheumatoid arthritis," Balliere's Clin. Rheum. 9(4):633-652 (Nov. 1995).
Feldman, M. et al., "TNF.alpha. Is an Effective Therapeutic Target for Rheumatoid Arthritis," Ann. N.Y. Acad. Sci. 766:272-278 (Nov. 1995).
Fendly, B.M. et al., "Murine Monoclonal Antibodies Defining Neutralizing Epitopes on Tumor Necrosis Factor," Hybridoma 6(4):359-370 (1987).
Gruss, H-J. and S.K. Dower, "Tumor Necrosis Factor Ligand Superfamily: Involvement in the Pathology of Malignant Lymphomas," Blood 85(12):3378-3404 (Jun. 1995).
Hinshaw, L.B. et al., "Survival of Primates in LD.sub.100 Septic Shock Following Therapy With Antibody to Tumor Necrosis Factor (TNF.alpha.)," Circ. Shock 30:279-292 (1990).
Hirai, M. et al., "Production and characterization of monoclonal antibodies to human tumor necrosis factor," J. Immunol. Methods 96:57-62 (1987).
Kriegler, M. et al., "A Novel Form of TNF/Cachectin Is a Cell Surface Cytotoxic Transmembrane Protein: Ramifications for the Complex Physiology of TNF," Cell 53:45-53 (1988).
Liang, C-M. et al., "Production and Characterization of Monoclonal Antibodies Against Recombinant Human Tumor Necrosis Factor/Cachectin," Biochem. Biophys. Res. Comm. 137(2):847-854 (1986).
Mathison, J.C. et al., "Participation of Tumor Necrosis Factor in the Mediation of Gram Negative Bacterial Lipopolysaccharide-induced Injury in Rabbits," J. Clin. Invest. 81(6):1925-1937 (1988).
Meager, A. et al., "Preparation and Characterization of Monoclonal Antibodies Directed Against Antigenic Determinants of Recombinant Human Tumour Necrosis Factor (rTNF)," Hybridoma 6(3):305-311 (1987).
Moller, A. et al., "Monoclonal Antibodies to Human Tumor Necrosis Factor .alpha.:In Vitro and In Vivo Application," Cytokine 2(3):162-169 (1990).
Opal, S.M. et al., "Efficacy of a Monoclonal Antibody Directed against Tumor Necrosis Factor in Protecting Neutropenic Rats from Lethal Infection with Pseudomonas aeruginosa," J. Infect. Dis. 161:1148-1152 (1990).
Shimamoto, Y. et al., "Monoclonal antibodies against human recombinant tumor necrosis factor: prevention of endotoxic shock," Immunol. Letters 17:311-318 (1988).
Silva, A.T. et al., "Prophylactic and Therapeutic Effects of a Monoclonal Antibody to Tumor Necrosis Factor-.alpha. in Experimental Gram-Negative Shock," J. Infect. Dis. 162:421-427 (1990).
Smith, R.A. and C. Baglioni, "The Active Form of Tumor Necrosis Factor Is a Trimer," J. Biol. Chem. 262(15):6951-6954 (1987).
Tracey, K.J. et al., "Anti-cachetin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia," Nature 330(17):662-664 (1987).
Tracey, K.J. and A. Cerami, "Tumor necrosis factor: An updated review of its biology," Crit. Care Med. 21(10):S415-S422 (1993).
van der Poll, T. and S F. Lowry, "Tumor Necrosis Factor in Sepsis: Mediator of Multiple Organ Failure or Essential Part of Host Defense?," Shock 3(1):1-12 (Jan. 1995).
Wherry, J.C. et al., "Tumor necrosis factor and the therapeutic potential of anti-tumor necrosis factor antibodies," Crit. Care Med. 21(10):S436-S440 (1993).
Database EST-STN on MASPAR search, WashU-Merck EST Project, (St. Louis, Mo, USA), No. R38487, from Hillier et al., "yf60c04.s1 Homo sapiens cDNA clone 26749 3'," (May 1995).
Database EST-STN on MASPAR search, WashU-Merck EST Project, (St. Louis, MO., USA) No. R41403, from Hillier et al., "yf94c12.s1 Homo sapiens cDNA clone 30225 3'," (May 1995).
Database EST-STN on MASPAR search, GenBank at National Library of Medicine, No. S78214, from Miki et al., "Disruption of the APC gene by retrotransposal insertion of L1 sequence in a colon cancer," Cancer Research 52(3):643-645 (1992).
EMBL/Genbank/DDBJ Data Banks, No. P41086, EMBL U02603, from Wood, "Putative Succinate Dehydrogenase 15 KD Hydrophobic Protein" (Feb. 1995).
International Search Report for Application No. PCT/US96/13282, mailed Nov., 1996.

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