Polynucleotides encoding herg-3

Details Polynucleotides encoding herg-3 Polynucleotides encoding herg-3

1997-10-22

1999-11-16

Teng, Sally

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 4352523, 43525411, 4353201, 435325, C12N 1512

Patent

active

059860812

ABSTRACT:
Novel genes in the erg subfamily of potassium channel proteins in humans are described. This family of proteins, and the genes encoding the proteins, are implicated in the development of long Q-T syndrome rare, but often fatal, cardiac arrhythmia.

REFERENCES:
Curran et al. "A Molecular Basis for Cardiac Arrhythmia: Herg Mutations Cause Long QT Syndrome", Cell, 80: 795-803 (1995).
Hoffman et al., "Overexcited or Inactive: Ion Channels in Muscle Disease", Cell, 80: 681-686 (1995).
Miller, Christopher, "The Inconstancy of the Human Heart", Nature, 379: 767-768 (1996).
Sanguinetti et al., "Spectrum of HERG K.sup.+ -channel Dysfunction in an Inherited Cardiac Arrhythmia", Proc. Natl. Acad. Sci., 93: 2208-2212 (1996).
Sanguinetti et al., "A Mechanistic Link Between an Inherited and an Acquired Cardiac Arrhythmia: HERG Encodes the I.sub.kr Potassium Channel", 81: 1-20 (1995).
Smith et al., "The Inward Rectification Mechanism of the HERG Cardiac Potassium Channel", Nature, 379: 833-836 (1996).
Titus et al., "The Drosophila erg K.sup.+ Channel Polypeptide is Encoded by the Seizure Locus", J. Neuroscience, 17(3): 875-881 (1997).
Trudeau et al., "HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family", Science, 269: 92-95 (1995).
Wang et al., "Positional Cloning of a Novel Potassium Channel Gene: KVLQT1 Mutations in Cause Cardiac Arrhythmias", Nature Genetics, 12:17-23 (1996).
Warmke et al., "A Family of Potassium Channel Genes Related to eag in Drosophila and Mammals", Proc. Natl. Acad. Sci., 97: 3438-3442 (1993).
Welsh et al., "Ion Channels Lose the Rhythm", Nature, 376(24): 640-641 (1995).
Editoral, "Third and Long (QT)", Nature Genetics, 12(1): 1-2 (1996).

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