Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-04-11
1999-06-29
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 4353201, 435325, 435243, 536 231, 536 2351, C12N 121, C12N 1512, C12N 1563, C12N 500
Patent
active
059167696
ABSTRACT:
The present invention discloses a novel cDNA isolated from human osteoclastoma tissue which encodes a novel polypeptide identified herein as Extracellular/Epidermal Growth Factor HCABA58X owing in part to the presence in its amino acid sequence of epidermal growth factor (EGF) domains characteristic of the EGF family of polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides. Also disclosed are antagonists against such polypeptides and their uses. Also disclosed are diagnostic assays for detecting altered levels of the polypeptides of the present invention and mutations in the nucleic acid sequences which encode such polypeptides.
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Salomon et al., 1995, Critical Rev. Oncol. Hematol. 19:183-232.
Olsen Henrik S.
Ruben Steven M.
Brookes A. Anders
Human Genome Sciences Inc.
Kenny Joseph J.
Saoud Christine
Ulm John
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