Polynucleotides encoding disorazole polyketide synthase...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S320100, C435S252000, C435S325000, C530S350000, C530S300000, C536S023100

Reexamination Certificate

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10729802

ABSTRACT:
The sequence of the disorazole polyketide synthase protein gene is disclosed. Domains of disorazole polyketide synthase and polynucleotides encoding them are provided. Methods to prepare disorazoles in pharmaceutically useful quantities are described, as are methods to prepare disorazole analogs and other polyketides using the polynucleotides encoding disorazole polyketide synthase domains or modifying enzymes.

REFERENCES:
patent: 4874748 (1989-10-01), Katz et al.
patent: 5063155 (1991-11-01), Cox et al.
patent: 5098837 (1992-03-01), Beckmann et al.
patent: 5149639 (1992-09-01), Katz et al.
patent: 5672491 (1997-09-01), Khosla et al.
patent: 5686295 (1997-11-01), Jaoua et al.
patent: 5712146 (1998-01-01), Khosla et al.
patent: 5830750 (1998-11-01), Khosla et al.
patent: 5843718 (1998-12-01), Khosla et al.
patent: 6410301 (2002-06-01), Julien et al.
patent: 6509455 (2003-01-01), Ashley et al.
patent: WO 93/13663 (1993-07-01), None
patent: WO 95/08548 (1995-03-01), None
patent: WO 97/02358 (1997-01-01), None
patent: WO 98/27203 (1998-06-01), None
Wells, Biochemistry, vol. 29, pp. 8509-8517, 1990.
Seffernick et al. ,J. Bacteriology, vol. 183, pp. 2405-2410, 2001.
Guo et al.,PNAS, vol. 101, No. 25, pp. 9205-9210, 2004.
Cheng, Y.-Q. et al. (2002). “Identification and Localization of the Gene Cluster Encoding Biosynthesis of the Antitumor Macrolactam Leinamycin inStreptomyces atroolivaceusS-140,”Journal of Bacteriology184(24):7013-7024.
Cheng, Y.-Q et al., (2003). “Type I Polyketide Synthase Requiring a Discrete Acyltransferase for Polyketide Biosynthesis,”PNAS100(6):3149-3154.
Elnakady, Y. A. et al. (2004). “Disorazol A1, A Highly Effective Antimitotic Agent Acting on Tubulin Polymerization and Inducing Apoptosis in Mammalian Cells,”Biochemical Pharmacology67:927-935.
Hartung, I.V. et al. (2002). “Toward the Total Synthesis of Disorazole A1and C1: Asymmetric Synthesis of a Masked Southern Segment,”Organic Letters4(19):3239-3242.
Irschik, H. et al. (1995). “Disorazol A, an Efficient Inhibitor of Eukaryotic Organisms Isolated from Myxobacteria,”The Journal of Antibiotics48(1):31-35.
Jansen, R. et al. (1994). “Disorazoles, Highly Cytotoxic Metabolites from the Sorangicin-Producing BacteriumSorangium cellulosum, Strain So ce12,”Liebigs Ann. Chem. 759-773.
Piel, J. (2002). “A Polyketide Synthase-Peptide Synthetase Gene Cluster from an Uncultured Bacterial Symbiont ofPaederusBeetles,”PNAS USA99(22):14002-14007.
Tang, G-L et al. (2004). “Leinamycin Biosynthesis Revealing Unprecedented Architectural Complexity For a Hybrid Polyketide Synthetase and Nonribosomal Peptide Synthetase,”Chemistry and Biology11:33-45.

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