Polynucleotides encoding CMV neutralizing proteins

Details Polynucleotides encoding CMV neutralizing proteins Polynucleotides encoding CMV neutralizing proteins

1995-05-24

1998-11-10

Mosher, Mary E.

Chemistry: molecular biology and microbiology

Vector, per se

435325, 435 693, 435 5, 4351721, 435 691, 4352523, 536 2372, C12N 1538, C12N 1021, C12N 170

Patent

active

058343075

ABSTRACT:
The present invention provides recombinant polypeptides derived from CMV glycoprotein gB and truncated fragments thereof which contain at least one epitope which is immunologically identifiable with one encoded by the CMV genome. The complete characterization of the gB protein, including the identity of glycoprotein gp55, permits the production of polypeptides which are useful as standards or reagents in diagnostic tests and/or as components of vaccines. This invention provides recombinant polypeptides and recombinant polynucleotides encoding these polypeptides wherein a neutralizing epitope of gB is localized within gp55.

REFERENCES:
patent: 4313927 (1982-02-01), Fridlender
patent: 4460689 (1984-07-01), Foor et al.
patent: 4554101 (1985-11-01), Hopp
patent: 4689225 (1987-08-01), Pereira
patent: 5043281 (1991-08-01), Masuho et al.
patent: 5124440 (1992-06-01), Gahrz et al.
patent: 5126130 (1992-06-01), Lussenhop et al.
Britt et al., J. Virol. (1986) 58:(1):185-191.
Britt, Virology (1984) 135:369-378.
Cranage et al., EMBO J. (1986) 5(11):3057-3063.
Darnell et al., Eds., "Molecular Cell Biology" (1986) Scientific American Books, Inc., W.H. Freeman and Company Publishers, New York, pp. 954-957.
Gonczol et al., J. Virol. (1986) 58(2):661-664.
Law et al., J. Med. Virol. (1985) 17:155-166.
Mach et al., J. Gen. Virol. (1986) 67:1461-1467.
Meter et al., J. Virol. (1988) 62:(7):2243-2250.
Nowak et al., Virology (1984) 132:325-338.
Pereira et al., Virology (1984) 139:73-86.
Pereira et al., Infection & Immunity (1982) 36(3):933-942.
Quinnan et al., Annals of Internal Medicine (1984) 101:478-483.
Rasmussen et al., J. Virol. (1985) 55(2):274-280.
Rasmussen et al., Proc. Natl. Acad. Sci. (1984) 81:876-880.
Rider et al., 12th International Herpesvirus Workshop Jul. 30-Aug. 4, 1987, p. 148.
Southern et al., J. Mol. Biol. (1975) 98:503-517.
Spaete et al., Virology (1988) 167(1):207-255.
Spaete et al., 12th International Herpesvirus Workshop Jul. 30-Aug. 4, 1987, p. 165.
Stannard et al., 12th International Herpesvirus Workshop Jul. 30-Aug. 4, 1987, p. 112.
Stinski et al., J. Virol. (1976) 19(2):594-609.
Pachl et al. Expression of Cell-Associated and Secreted Forms of Herpes Simplex Virus Type 1 Glycoprotein GB in Mammalian Cells. J. Virol. 61:315-325, (1987).
Cranage et al. Identification of the Human Cytomegalovirus Glycoprotein B Gene and Induction of Neutralizing Antibodies via its Expression in Recombinant Vaccinia Virus The EMBO J. 5-3057-3063 (1986).

Affiliated with

Also associated with

Rating

Polynucleotides encoding CMV neutralizing proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polynucleotides encoding CMV neutralizing proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotides encoding CMV neutralizing proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1515899