Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-08-21
2007-08-21
Li, Ruixiang (Department: 1646)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S325000, C435S252300, C435S254110, C435S254200, C435S320100, C536S023400
Reexamination Certificate
active
10988267
ABSTRACT:
The present invention relates to a chimeric chemokine receptor comprising two components: a first sequence comprising the N terminus through the last residue of the seven helix TM region of a first chemokine receptor joined with a second sequence comprising the C terminus of a second chemokine receptor extending from the first intracellular residue of the chemokine receptor to the last residue of the chemokine receptor. The chimeric chemokine receptor can be employed in various applications, such as ligand binding and screening assays and signalling assays. The chimeric chemokine receptor can also form a component of a chemokine receptor modulator design program.
REFERENCES:
patent: 5707815 (1998-01-01), Charo et al.
patent: 2004/0082616 (2004-04-01), Duncia et al.
Lu, et al., “Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains”, PNAS, vol. 94, pp. 6426-6431 (1997).
Choe, et al., “The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates”, Cell, vol. 85, pp. 1135-1148 (1996).
NCBI Entrez Accession No. AF545480 (gi:23267189), Rieder, M.J. et al., Sep. 22, 2002.
NCBI Entrez Accession No. D10924 (gi:219868), Nomura, H. et al., Feb. 8, 2003.
NCBI Entrez Accession No. D10925 (gi:219862), Nomura, H. et al., Feb. 8, 2003.
NCBI Entrez Accession No. D29984 (gi:531246), Yamagami, S. et al., Feb. 8, 2003.
NCBI Entrez Accession No. L01639 (gi:189313), Jazin, E.E. et al., Mar. 9, 1994.
NCBI Entrez Accession No. L06797 (gi:414929), Herzog, H. et al., Nov. 10, 1993.
NCBI Entrez Accession No. L08176 (gi:183484), Birkenbach, M. et al., Dec. 31, 1994.
NCBI Entrez Accession No. L09230 (gi:179984), Neote, K. et al., Dec. 31, 1994.
NCBI Entrez Accession No. L10918 (gi:292416), Gao, J.L. et al., Jun. 12, 1993.
NCBI Entrez Accession No. L19591 (gi:559049), Holmes, W.E. et al., Jan. 6, 1995.
NCBI Entrez Accession No. L19592 (gi:559051), Holmes, W.E. et al., Jan. 6, 1995.
NCBI Entrez Accession No. L19593 (gi:559053), Murphy, P.M. et al., Jan. 6, 1995.
NCBI Entrez Accession No. L31581 (gi:468319), Schweickart, V.L. et al., Aug. 10, 1995.
NCBI Entrez Accession No. L31584 (gi:468314), Schweickart, V.L. et al., Feb. 11, 2002.
NCBI Entrez Accession No. L36149 (gi:598154), Heiber, M. et al., Feb. 28, 1995.
NCBI Entrez Accession No. M68932 (gi:186369), Holmes, W.E. et al., Jan. 6, 1995.
NCBI Entrez Accession No. M73969 (gi:186516), Murphy, P.M. et al., Dec. 8, 1995.
NCBI Entrez Accession No. M94582 (gi:186377), Murphy, P.M. et al., Apr. 27, 1993.
NCBI Entrez Accession No. M99293 (gi:292516), Federsppiel, B. et al., Mar. 10, 1994.
NCBI Entrez Accession No. M99412 (gi:576678), Sprenger, H. et al., Apr. 22, 1998.
NCBI Entrez Accession No. U03882 (gi:472555), Charo, I.F. et al., Jun. 22, 1994.
NCBI Entrez Accession No. U03905 (gi:472557), Charo, I.F. et al., Jun. 22, 1994.
NCBI Entrez Accession No. U11869 (gi:511801), Ahuja, S.K. et al., Aug. 23, 2002.
NCBI Entrez Accession No. U11870 (gi:511804), Ahuja, S.K. et al., Mar. 28, 1995.
NCBI Entrez Accession No. U13667 (gi:577414), Marchese, A. et al., Apr. 1, 1995.
NCBI Entrez Accession No. U20350 (gi:665580), Raport, C.J. et al., Mar. 9, 1996.
NCBI Entrez Accession No. U28694 (gi:1199579), Combadiere, C. et al., May 16, 1996.
NCBI Entrez Accession No. U28934 (gi:881599), Combadiere, C. et al., Feb. 9, 1996.
NCBI Entrez Accession No. U32674 (gi:1002740), Marchese, A. et al., Jun. 5, 1996.
NCBI Entrez Accession No. U45982 (gi:1245054), Lautens, L.L. et al., Apr. 2, 1996.
NCBI Entrez Accession No. U45983 (gi:2231165), Tiffany, H.L. et al., Sep. 30, 2002.
NCBI Entrez Accession No. U45984 (gi:2246432), Baba, M. et al., Jul. 9, 1997.
NCBI Entrez Accession No. U49727 (gi:1477560), Ponath, P.D. et al., Oct. 4, 1996.
NCBI Entrez Accession No. U51241 (gi:1480480), Daugherty, B.L. et al., Oct. 9, 1996.
NCBI Entrez Accession No. U54994 (gi:1457945), Raport, C.J. et al., Jul. 25, 1996.
NCBI Entrez Accession No. U57840 (gi:1502408), Combadiere, C. et al., Oct. 18, 1996.
NCBI Entrez Accession No. U60000 (gi:1515434), McCoy, R. et al., Aug. 30, 1996.
NCBI Entrez Accession No. U62556 (gi:1468978), Napolitano, M. et al., Mar. 11, 2002.
NCBI Entrez Accession No. U68032 (gi:1870668), Liao, F. et al., Mar. 6, 1997.
NCBI Entrez Accession No. U73531 (gi:2209287), Liao, F. et al., Jun. 23, 1997.
NCBI Entrez Accession No. U80924 (gi:1773032), Wong, L.M. et al., Jul. 24, 1997.
NCBI Entrez Accession No. X65858 (gi:312046), Mollereau, C. et al., Jun. 25, 1997.
NCBI Entrez Accession No. X68149 (gi:29459), Dobner, T. et al., Nov. 1, 1999.
NCBI Entrez Accession No. X68829 (gi:840783), Barella, L. et al., Oct. 18, 1995.
NCBI Entrez Accession No. X71635 (gi:297099), Loetscher, M. et al., Feb. 15, 1994.
NCBI Entrez Accession No. X84702 (gi:673391), Burgstahler, R. et al., Feb. 6, 1996.
NCBI Entrez Accession No. X85740 (gi:1370103), Power, C.A. et al., Jun. 4, 1996.
NCBI Entrez Accession No. X91492 (gi:1262810), Samson, M. et al., Oct. 4, 1996.
NCBI Entrez Accession No. X95876 (gi:1552845), Loetscher, M. et al., Sep. 9, 2004.
NCBI Entrez Accession No. Y08456 (gi:2465081), Samson, M. et al., Sep. 9, 2004.
NCBI Entrez Accession No. Z79782 (gi:1668735), Zaballos, A. et al., Nov. 13, 1996.
Adachi, T. et al., “The Functional Role of Rho and Rho-Associated Coiled-Coil Forming Protein Kinase in Eotaxin Signaling of Eosinophils”, The Journal of Immunology, vol. 167, pp. 4609-4615 (2001).
Alkhatib, G. et al., “Determinants of HIV-1 Coreceptor Function on CC Chemokine Receptor 3”, The Journal of Biological Chemistry, vol. 272, No. 33, pp. 20420-20426 (1997).
Baba, M. et al., “Identification of CCR6, the Specific Receptor for a Novel Lymphocyte-directed CC Chemokine LARC”, The Journal of Biological Chemistry, vol. 272, No. 23, pp. 14893-14898 (1997).
Baggiolini, M. et al., “Chemokines and leukocyte traffic”, Nature, vol. 392, pp. 565-568 (1998).
Baggiolini, M. et al., “Human Chemokines: An Update”, Annu. Rev. Immunol., vol. 15, pp. 675-705 (1997).
Castro-Fernández, C. et al., “Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus”, Molecular and Cellular Endocrinology, vol. 191, pp. 149-156 (2002).
Charo, I.F. et al., “Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails”, Proc. Natl. Acad. Sci. USA, vol. 91, pp. 2752-2756 (1994).
Combadiere, C. et al., “Cloning and Functional Expression of a Human Eosinophil CC Chemokine Receptor”, The Journal of Biological Chemistry, vol. 270, No. 27, pp. 16491-16494, 30235 (correction) (1995).
Combadiere, C. et al., “Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1α, MIP-1β, and RANTES”, Journal of Leukocyte Biology, vol. 60, pp. 147-152 (1996).
Combadiere, C. et al., “Identification of CX3CR1: A Chemotactic Receptor for the Human CX3C Chemokine Fractalkine and a Fusion Coreceptor for HIV-1”, The Journal of Biological Chemistry, vol. 273, No. 37, pp. 23799-23804 (1998).
Daugherty, B.L. et al., “Cloning, Expression, and Characterization of the Human Eosinophil Eotaxin Receptor”, J. Exp. Med., vol. 183, pp. 2349-2354 (1996).
El-Shazly, A. et al., “Novel Association of the Src Family Kinases, Hck and c-Fgr, with CCR3 Receptor Stimulation: A Possible Mechanism for Eotaxin-Induced Human Eosinophil Chemotaxis”, Biochemical and Biophysical Research Communications, vol. 264, No. 1, pp. 163-170 (1999).
Elsner, J. et al., “Eotaxin-2 activates chemotaxis-related events and release of reactive oxygen species via pertussis toxin-sensitive G proteins in human eosinophils”, Eur. J. Immunol., vol. 28, pp. 2152-2158 (1998).
Elsner, J. et al., “Human eotaxin represents a potent activator of the respiratory burst of human eosinophils”, Eur. J. Immunol., vol.
Carter Percy H.
Davies Paul
Dinchuk Joseph E.
Scherle Peggy Ann
Solomon Kimberly A.
Bristol--Myers Squibb Company
Li Ruixiang
Spalding Todd
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