Polynucleotides encoding ATP synthase coupling factor 6

Details Polynucleotides encoding ATP synthase coupling factor 6 Polynucleotides encoding ATP synthase coupling factor 6

1997-03-31

1998-12-15

Spector, Lorraine

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 6, 4352523, 4353201, 435325, 530350, 536 231, 536 235, 536 243, 536 2431, C12P 2100, C12N 121, C07H 2104, C07K 1446

Patent

active

058495274

ABSTRACT:
The present invention provides a human mitochondrial F6 subunit (HMF6) and polynucleotides which encode HMF6. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HMF6.

REFERENCES:
Javed et al. Human mitochondrial ATP synthase: cloning cDNA for the nuclear-encoded precursor of coupling factor 6. GENE, (1991 Jan. 15) 97 (2) 307-310, Jan. 1991.
Walker et al. ATP synthase from bovine mitochondria: sequences of imported precursors of oligomycin sensitivity conferral protein, factor 6, and adenosinetriphosphatase inhibitor protein. Biochemistry, (1987 Dec. 29) 26 (26) 8613-8619, Dec. 1987.
Tracer et al. Rat mitochondrial coupling factor 6: molecular cloning of a cDNA encoding the imported precusor. GENE, (1992 Jul. 15) 116 (2) 291-292, Jul. 1992.
Higuti et al. Molecular cloning of cDNA for the import precursor of human coupling factor 6 of H(+)-ATP synthase in mitochondria. Biochem. Biophys. Res. Comm., (1991 Jul. 31) 178 (2) 793-9, Jul. 1991.
Higuti et al. cDNA cloning and sequencing for the import precursor of coupling factor 6 H(+)-ATP synthase from rat liver mitochondria. Biochem. Biophys. Res. Comm., (1990 Sep. 28) 171 (3) 1079-86, Sep. 1990.
Rocha et al. GenBank. Accesion number U77128, 21 Nov. 1996.
Walker, J.E. et al., "The role of the stalk in the coupling mechanism of F.sub.1 F.sub.0 -ATPases" FEBS Lett. 346: 39-43 (1994).

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