Polynucleotides encoding a novel human G-protein coupled...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S252300, C435S320100, C435S325000, C435S471000, C536S023500

Reexamination Certificate

active

07049096

ABSTRACT:
The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

REFERENCES:
patent: 5849902 (1998-12-01), Arrow et al.
patent: WO00/40724 (2000-07-01), None
patent: WO0100673 (2001-01-01), None
patent: WO 01/02563 (2001-01-01), None
patent: WO0102563 (2001-01-01), None
patent: WO0125430 (2001-04-01), None
patent: WO0144281 (2001-06-01), None
patent: WO 02/061087 (2001-08-01), None
patent: WO0168848 (2001-09-01), None
patent: WO01/98351 (2001-12-01), None
patent: WO0210387 (2002-02-01), None
patent: WO0222665 (2002-03-01), None
patent: WO0229050 (2002-04-01), None
Skolnick et al. Trends in Biotech. 18:34-39, 2000.
Bork P. Genome Research 10:398-400, 2000.
Doerks et al. Trends in Genetics 14:248-250, 1998.
Smith et al. Nature Biotechnology 15:1222-1223, 1997.
Brenner SE. Trends in Genetics 15:132-133, 1999.
Bork, et al. Trends in Genetics 12:425-427, 1996.
Stadel, et al., “Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery”, TIPS, Vol. 18, pp. 430-437 (1997).
U.S. Appl. No. 60/306,803, Feder et al., filed Jul. 20, 2001.
NCBI Entrez Accession No. AA058394 (gi: 1551409), Sep. 19, 1996.
NCBI Entrez Accession No. AAB36682 (gi: 1685051), Gray, J.X. et al., Sep. 30, 2002.
NCBI Entrez Accession No. AC026333 (gi:24431582), Muzny, D.M. et al., Mar. 15, 2003.
NCBI Entrez Accession No. AL161776 (gi:9931705), Sims, S., Jun. 13, 2001.
NCBI Entrez Accession No. AL551728 (gi:45856521), Feb. 15, 2001.
NCBI Entrez Accession No. AW357690 (gi:6861696), Feb. 3, 2000.
NCBI Entrez Accession No. AW657930 (gi:7423756), Apr. 5, 2000.
NCBI Entrez Accession No. AW998346 (gi:8258580), Jun. 5, 2000.
NCBI Entrez Accession No. BAA34478 (gi:3882237), Nagase, T. et al., Jun. 16, 1999.
NCBI Entrez Accession No. BAA82518 (gi:5525078), Abe, J. et al., Jul. 22, 1999).
NCBI Entrez Accession No. BAB31767 (gi:12859760, Carninci, P. et al., Apr. 30, 2004.
NCBI Entrez Accession No. BE243318 (gi:9095053), Jul. 13, 2000.
NCBI Entrez Accession No. BF160755 (gi:11040862), Oct. 27, 2000.
NCBI Entrez Accession No. BG757374 (gi:140608027), May 14, 2001.
NCBI Entrez Accession No. BI518500 (gi:15343292), Aug. 28, 2001.
NCBI Entrez Accession No. BI540125 (gi:15381237), Aug. 30, 2001.
NCBI Entrez Accession No. BJ062663 (gi:17424297), Dec. 7, 2001.
NCBI Entrez Accession No. BJ062997 (gi: 17470757), Dec. 10, 2001.
NCBI Entrez Accession No. BM052876 (gi: 16808668), Nov. 8, 2001.
NCBI Entrez Accession No. BM147960 (gi:17168247), Nov. 30, 2001.
NCBI Entrez Accession No. BM148818 (gi: 17169886), Nov. 30, 2001.
NCBI Entrez Accession No. BM193863 (gi: 17652455), Dec. 13, 2001.
NCBI Entrez Accession No. CAB37294 (gi:4456467), Zendman, A.J. et al., Aug. 17, 1999.
NCBI Entrez Accession No. CAB42901 (gi:4826465), Mashreghi-Mohammadi, M., Nov. 23, 1999.
NCBI Entrez Accession No. NP_005747 (gi:5031733) Obermann, H. et al., Sep. 3, 2004.
NCBI Entrez Accession No. NP_061370 (gi:9256531), Kawai, J. et al., Apr. 7, 2003.
AbdAlla, S. et al., “AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration”, Nature, vol. 407, pp. 94-98 (2000).
Aggarwal, B.B., “Apoptosis and Nuclear Factor-κB: A Tale of Association and Dissociation”, Biochemical Pharmacology, vol. 60, pp. 1033-1039 (2000).
Akbar, G.K.M. et al., “Molecular Cloning of a Novel P2 Purinoceptor form Human Erythroleukemia Cells”, The Journal of Biological Chemistry, vol. 271, No. 31, pp. 18363-18367 (1996).
Altschul, S.F. et al., “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs”, Nucleic Acids Research , vol. 25, No. 17, pp. 3389-3402 (1997).
Applebury, M.L. et al., “Molecular Biology of the Visual Pigments”, Vision Res., vol. 26, No. 12, pp. 1881-1895 (1986).
Attwood, T.K. et al., “Multiple sequence alignment of protein families showing low sequence homology: a methodological approach using database pattern-matching discriminators for G-protein linked receptors”, Gene, vol. 98, pp. 153-159 (1991).
Aust, G. et al., “CD97: A Dedifferentiation Marker in Human Thyroid Carcinomas”, Cancer Research, vol. 57, pp. 1798-1806 (1997).
Baldwin, A.S., “Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB”, The Journal of Clinical Investigation, vol. 107, No. 3, pp. 241-246 (2001).
Baldwin, J.M., “Structure and function of receptors coupled to G proteins”, Current Opinion in Cell Biology, vol. 6, pp. 180-190 (1994).
Baldwin, Jr., A.S., “The transcription factor NF-κB and human disease”, The Journal of Clinical Investigation, vol. 107, No. 1, pp. 3-6 (2001).
Barnard, E.A. et al., “G protein-coupled receptors for ATP and other nucleotides: a new receptor family”, Trends in Pharmacological Sciences, vol. 15, pp. 67-70 (1994).
Basu, S. et al., “The DNA-Dependent Protein Kinase Participates in the Activation of NFκB Following DNA Damage”, Biochemical and Biophysical Research Communications, vol. 247, No. 1, pp. 79-83 (1998).
Bateman, A. et al., “The Pfam Protein Families Database”, Nucleic Acids Research, vol. 28, No. 1, pp. 263-266 (2000).
Baud, V. et al., “EMR1, an Unusual Member in theFamily of Hormone Receptors with Seven Transmembrane Segments”, Genomics, vol. 26, pp. 334-344 (1995).
Baud, V. et al., “Signal transduction by tumor necrosis factor and its relatives”, Trends in Cell Biology, vol. 11, No. 9, pp. 372-377 (2001).
Bause, E., “Structural requirements of N-glycosylation of proteins: Studies with proline peptides as conformational probes”, Biochem. J., vol. 209, pp. 331-336 (1983).
Bolander, F.F., Molecular Endocrinology, Second Edition, Academic Press, Inc., publ., pp. 162-176 (1994).
Bradbury, A.F. et al., “Biosynthesis of the C-Terminal Amide in Peptide Hormones”, Bioscience Reports, vol. 7, No. 12, pp. 907-916 (1987).
Branchek, T., “More serotonin receptors?”, Current Biology, vol. 3, No. 5, pp. 315-317 (1993).
Chapot-Chartier, M.-P. et al., “Cloning and Sequencing of pepC, a Cysteine Aminopeptidase Gene fromLactococcus lactissubsp. cremoris AM2”, Applied and Environmental Microbiology, vol. 59, No. 1, pp. 330-333 (1993).
Cornfield, L.J. et al., “[3H]2-Phenylaminoadenosine ([3H]CV 1808 Labels a Novel Adenosine Receptor in Rat Brain”, The Journal of Pharmacology and Experimental Therapeutics, vol. 263, No. 2, pp. 552-561 (1992).
Coughlin, S.R., “Expanding horizons for receptors coupled to G proteins: diversity and disease”, Current Opinion in Cell Biology, vol. 6, pp. 191-197 (1994).
Desdouets, C. et al., “p27: a pleiotropic regulator of cellular phenotype and a target for cell cycle dysregulation in cancer”, Pathol. Biol., vol. 48, pp. 203-210 (2000).
Draetta, G.F., “Mammalian G1cyclins”, Current Opinion in Cell Biology , vol. 6, pp. 842-846 (1994).
Dufour, E., “Sequence homologies, hydrophobic profiles and secondary structures of cathepsins B, H and L: comparison with papain and actinidin”, Biochimie, vol. 70, pp. 1335-1342 (1988).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polynucleotides encoding a novel human G-protein coupled... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polynucleotides encoding a novel human G-protein coupled..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotides encoding a novel human G-protein coupled... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3559235

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.