Polynucleotides encoding a novel human 11cb splice variant

Details Polynucleotides encoding a novel human 11cb splice variant Polynucleotides encoding a novel human 11cb splice variant

1997-12-03

2000-03-07

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435325, 4353201, 4352523, 536 231, 536 235, C12N 1512, C12N 1563, C12N 1585

Patent

active

060338725

ABSTRACT:
Human 11cb splice variant polypeptides and DNA (RNA) encoding such an 11cb splice variant and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such an 11cb splice variant for the treatment of infections, such as bacterial, fungal, protozoan and viral infections, particularly infection caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; both acute and congestive heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation; dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others. Antagonists against such an 11cb splice variant and their use as a therapeutic to treat infections, such as bacterial, fungal, protozoan and viral infections, particularly infection caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; both acute and congestive heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy and psychotic and neurological disorders; and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the 11cb splice variant and for detecting altered levels of the polypeptide in a host.

REFERENCES:
Gress et al. "A Pancreatic cancer-specific expression profile", Oncogene, vol. 13, pp. 1819-1830 (1996).
GeneBank Accession #U71092.
Kolakowski, Jr., Lee F., et al. "Characterization of a human gene related to genes encoding somatostatin receptors", FEBS Letters 398:253-258 (1996).
Rudinger, In "Peptide Hormones" (ed. J. A. Parsons) University Park Press, Baltimore, pp. 1-7, 1976.
Vanetti et al., GenBank Accession # X68951 and S47713 (1992).
George et al "Current Methods in Sequence Comparison and Analysis" in Macro-Molecular Sequencing and Synthesis (1988) Alan R. Liss Publications, USA pp. 127-149.

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