Polynucleotides encoding a human leucine-rich repeat domain...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S252300, C435S254110, C435S254200, C435S320100, C536S023500, C536S024300

Reexamination Certificate

active

07129085

ABSTRACT:
The present invention provides novel polynucleotides encoding HLLRCR-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLLRCR-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly nervous system diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

REFERENCES:
patent: 2004/0018555 (2004-01-01), Anderson et al.
patent: WO 02/099062 (2002-12-01), None
Peer Bork and Eugene V. Koonin, Predicting functions from protein sequences—where are the bottlenecks? Nature Genetics 18:313-318, 1998.
NCBI Entrez Accession No. gi|12698137, Osada, N. et al., Jan. 10, 2002.
NCBI Entrez Accession No. gi|20535631, NCBI Annotation Project, May 13, 2002.
Osada, N. et al., “Prediction of unidentified human genes on the basis of sequence similarity to novel cDNAs from cynomolgus monkey brain”, Genome Biology, vol. 3, No. 1, Research, pp. 0006.1-0006.5.
U.S. Appl. No. 60/306,803, filed Jul. 20, 2001, Feder et al.
Altschul, et al., “Gapped Blast and PSI-Blast: a new generation of protein database search programs”, Nucleic Acids Res., vol. 25(17), pp. 3389-3402 (1997).
Bengtsson, et al., “The Primary Structure of a Basic Leucine-rich Repeat Protein, PRELP, Found in Connective Tissues”, JBC, vol. 270(43), pp. 25639-25644 (1995).
Buchanan, et al., “Structural and Functional Diversity in the Leucine-Rich Repeat Family of Proteins”, Prog. Biophys. Molec. Biol., vol. 65(1/2) pp. 1-44 (1996).
Collins, et al., “Molecular Characterization of the Maize Rp1-D Rust Resistance Haplotype and Its Mutants”, The Plant Cell, vol. 11, pp. 1365-1376 (1999).
Dixon, et al., “Increased levels of apoptosis in the prefusion neural folds underlie the craniofacial disorder, Treacher Collins syndrome”, Human Molec. Genetics, vol. 9(10), pp. 1473-1480 (2000).
Dixon, et al., “Genetic complexity of pathogen perception by plants: The example of Rcr3, a tomato gene required specifically by Cf-2”, PNAS, vol. 97(16), pp. 8807-8814 (2000).
Dixon, et al., “The Tomato Cf-5 Disease Resistance Gene and Six Homologs Show Pronounced Allelic Variation in Leucine-Rich Repeat Copy Number”, The Plant Cell, vol. 10, pp. 1915-1925 (1998).
Eldon, et al., “The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll”, Development, vol. 120, pp. 885-899 (1994).
Ellis, et al., “Structure and function of proteins controlling strain-specific pathogen resistance in plants”, Curr. Opin. Plant Biol., vol. 1, pp. 288-293 (1998).
Fong, et al., “Novel Proteins Interacting with the Leucine-rich Repeat Domain of Human Flightless-I Identified by the Yeast Two-Hybrid System”, Genomics, vol. 58, pp. 146-157 (1999).
Fournier, et al., “Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration”, Nature, vol. 409, pp. 341-346 (2001).
Gavrieli, et al., “Identification of Programmed Cell Death In Situ via Specific Labeling of Nuclear DNA Fragmentation”, J. Cell Biol., vol. 119(3), pp. 493-501 (1992).
Graham, et al., “Expression and genome organization of resistance gene analogs in soybean”, Genome, vol. 43, pp. 86-93 (2000).
Halfon, et al., “The Drosophila Toll Gene Functions Zygotically and Is Necessary for Proper Motoneuron and Muscle Development”, Developmental Biol., vol. 169, pp. 151-157 (1995).
Harton, et al., “Class II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression”, Molec. Cell. Biol., vol. 20(17), pp. 6185-6194 (2000).
Hayashi, et al., “Molecular Pathogenesis of Bernard-Soulier Syndrome”, Seminars Throm. Hemostasis, vol. 26(1), pp. 53-59 (2000).
He, et al., “Perception of Brassinosteroids by the Extracellular Domain of the Receptor Kinase BRI1”, Science, vol. 288, pp. 2360-2363 (2000).
Inohara, et al., “An Induced Proximity Model for NF-kB Activation in the Nod1/RICK and RIP Signaling Pathways”, JBC, vol. 275(36), pp. 27823-27831 (2000).
Inohara, et al., “Genes with homology to DFF/CIDEs found in Drosophila melanogaster”, Cell Death Differ., vol. 6, pp. 823-824 (1999).
Inohara, et al., “Genes with homology to mammalian apoptosis regulators identified in zebrafish”, Cell Death Differ., vol. 7, pp. 509-510 (2000).
Inohara, et al., “Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-kB”, JBC, vol. 274(21), pp. 14560-14567 (1999).
Iozzo, Renato V., “Matrix Proteoglycans: From Molecular Design to Cellular Function”, Annu. Rev. Biochem., vol. 67, pp. 609-652 (1998).
Jacobs, J. Roger, “Perturbed Glial Scaffold Formation Precedes Axon Tract Malformation in Drosophila Mutants”, J. Neurobiol., vol. 24(5), pp. 611-626 (1993).
Jacobs, et al., “Embryonic Development of Axon Pathways in the Drosophila CNS. I. A Glial Scaffold Appears Before the First Growth Cones”, J. Neurosci., vol. 9(7), pp. 2402-2411 (1989).
Jones, et al., “A Two-Step Adhesion Cascade for T Cell/Endothelial Cell Interactions under Flow Conditions”, J. Clin. Invest., vol. 94, pp. 2443-2450 (1994).
Kajava, A.V., “Structural Diversity of Leucine-rich Repeat Proteins”, J. Mol. Biol., vol. 277, pp. 519-527 (1998).
Koarada, et al., “B Cells Lacking RP105, A Novel B Cell Antigen, In Systemic Lupus Erythematosus”, Arthritis Rheumatism, vol. 42(12), pp. 2593-2600 (1999).
Kobe, et al., “Proteins with leucine-rich repeats”, Curr. Opin. Struc. Biol., vol. 5, pp. 409-416 (1995).
Kobe, et al., “The leucine-rich repeat: a versatile binding motif”, TIBS, vol. 19, pp. 415-421 (1994).
Lacy, et al., “Identification of FLRT1, FLRT2, and FLRT3: A Novel Family of Tansmembrane Leucine-Rich Repeat Proteins”, Genomics, vol. 62, pp. 417-426 (1999).
Liang, et al., “Mammalian Homologues of the Drosophila Slit Protein Are Ligands of the Heparan Sulfate Proteoglycan Glypican-1 in Brain”, JBC, vol. 274(25), pp. 17885-17892 (1999).
Lorenzo, et al., “Identification and Characterization of Asporin”, JBC, vol. 276(15), pp. 12201-12211 (2001).
Miyake, et al., “RP105, A Novel B Cell Surface Molecule Implicated in B Cell Activation, Is a Member of the Leucine-Rich Repeat Protein Family”, J. Immunol., vol. 154, pp. 3333-3340 (1995).
Nagasawa, et al., “Cloning of the cDNA for a New Member of the Immunoglobulin Superfamily (ISLR) Containing Leucine-Rich (LRR)”, Genomics, vol. 44, pp. 273-279 (1997).
Ng, et al., “Nogos and the Nogo-66 Receptor: Factors Inhibiting CNS Neuron Regeneration”, J. Neurosci. Res., vol. 67, pp. 559-565 (2002).
Richter, et al., “The evolution of disease resistance genes”, Plant Molec. Biol., vol. 42, pp. 195-204 (2000).
Satoh, et al., “Cytokines and neurotrophic factors fail to affect Nogo-A mRNA expression in differentiated human neurons: implications for inflammation-related axonal regeneration in the central nervous system”, Neuropath. Applied Neurobiol., vol. 28, pp. 95-106 (2002).
Schuster, et al., “Toll receptors: an expanding role in our understanding of human disease”, J. Leukocyte Biol., vol. 67, pp. 767-773 (2000).
Skaper, et al., “Cell signalling cascades regulating neuronal growth-promoting and inhibitory cues”, Prog. Neurobiology, vol. 65, pp. 593-608 (2001).
Schneider, et al., “Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosphilia

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polynucleotides encoding a human leucine-rich repeat domain... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polynucleotides encoding a human leucine-rich repeat domain..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotides encoding a human leucine-rich repeat domain... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3712457

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.