Polynucleotides encoding a cardiotrophin-like cytokine

Details Polynucleotides encoding a cardiotrophin-like cytokine Polynucleotides encoding a cardiotrophin-like cytokine

1998-06-29

2000-04-04

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 536 235, 536 231, 530351, C12N 1524, C07K 1454

Patent

active

060460350

ABSTRACT:
The present invention relates to a novel CLC protein which is a member of the IL-6 cytokine family. In particular, isolated nucleic acid molecules are provided encoding the human CLC protein. CLC polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CLC activity. Also provided are diagnostic methods for detecting cardiac and immune system-related disorders and therapeutic methods for treating cardiac and immune system-related disorders.

REFERENCES:
patent: 5741772 (1998-04-01), Chang
Sheng et al., (1996) Development 122:419-428.

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