Polynucleotides en coding porcine cytokines

Details Polynucleotides en coding porcine cytokines Polynucleotides en coding porcine cytokines

1993-10-08

1996-12-31

Ulm, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2351, 530351, 435 911, 4353201, 4352523, C12N 1519, C07K 1452

Patent

active

055895824

ABSTRACT:
A method of enhancing tolerance of a porcine transplant in a xenogeneic recipient by administering porcine bone marrow cells to the recipient and of enhancing proliferation and engraftment of the porcine bone marrow cells by exposing said cells to at least one substantially pure porcine cytokine and porcine cytokines that are substantially free of other porcine proteins and preferentially enhance the proliferation and engraftment of porcine bone marrow cells in the presence of bone marrow cells of other species. Protein and DNA sequence(s) for such porcine cytokines.

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Flanagan et al. Cell 64:1025-1035 (1991).
Martin et al. Cell 63:203-211 (1990).
Shull et al. Exp. Hematol 20:1118-1124 (1992).
Smith et al. J. Clinical Apherrsis 7:49-57 (1992).
Zhou et al. Biochin & Biophys Acta 1223:148-150 (1994).

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