Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-08-30
2005-08-30
Minnifield, N. M. (Department: 1645)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100, C435S091200, C435S091100, C435S007340, C435S975000, C536S023100, C536S024300, C536S024320, C536S024330, C536S023700
Reexamination Certificate
active
06936422
ABSTRACT:
The present invention pertains to polynucleotides derived fromstaphylococcalgenes encoding resistance to streptogramin A or to streptogramin B and chemically related compounds. This invention also relates to the use of the polynucleotides as oligonucleotide primers or probes for detectingStaphylococcalstrains that are resistant to streptogramin A or to streptogramin B and related compounds in a biological sample. In another embodiment, the present invention is directed to the full length coding sequences of thestaphylococcalgenes encoding for resistance to streptogramin A or to streptogramin B fromStaphylococcusand to the polypeptide expressed by these full length coding sequences. Further, this invention relates to the use of the expressed polypeptides to produce specific monoclonal or polyclonal antibodies that serve as detection means in order to characterize anystaphylococcalstrain carrying genes encoding resistance to streptogramin A or to streptogramin B.
REFERENCES:
patent: 5614395 (1997-03-01), Ryals et al.
patent: 5874224 (1999-02-01), Bandman et al.
patent: 5882888 (1999-03-01), Jorgensen
patent: 5994066 (1999-11-01), Bergeron et al.
patent: 6001564 (1999-12-01), Bergeron et al.
patent: 6506893 (2003-01-01), El Solh et al.
patent: 6570001 (2003-05-01), Solh et al.
patent: 2002/0102678 (2002-08-01), Soth et al.
patent: 2003/0158135 (2003-08-01), El Solh et al.
patent: 2003/0176679 (2003-09-01), El Solh et al.
patent: WO 96/08582 (1996-03-01), None
Jeanine Allignet et al.; “Distribution of Gene Encoding Resistance to Streptogramin A and Related Compounds AmongStaphylococciResistant to these Antibiotics,”Antimicrobial Agents and Chemotherapy, vol. 40(11), pp. 2523-2528; (1996).
Jeanine Allignet et al.; “Sequence of aStaphylococcal gene, vat, Encoding an Acetyltransferase Inactivating the A-type Compounds of Virginiamycin-like Antibiotics,”Gene, vol. 130(1), pp. 91-98; (1993).
Rosanna Rende-Fournier, et al.; “Identification of thesatA GeneEncoding a Streptogramin A Acetyltransferase inEnterococcus FaeciumBM4145,”Antimicrobial Agents and Chemotherapy, vol. 37(10), pp. 2119-2125; (1993).
Jeanine Allignet et al.; “Diversity Among the Gram-Positive Acetyltransferases Inactivating Streptogramin A and Structurally Related Compounds and Characterization of a NewStaphylococcalDeterminant, vatB,”Antimicrobial Agents and Chemotherapy, vol. 39(9), pp. 2027-2036; (1995).
Jeanine Allignet et al.; “Distribution of Gene Encoding Resistance toStreptograminA and Related Compounds AmongStaphylococciResistant to these Antibiotics,”Antimicrobial Agents and Chemotherapy, vol. 40(11), pp. 2523-2528; (1996).
Chang-Kwon Lee et al., “Identification and In Viv Functional Analysis of a Virginiamycin S Resistance Gene (varS) fromStreptomyces virginiae,” J. Bacteriology, 181/10, pp. 3293-3297; (1999).
Takaaki Hayashi et al., “Characterization of the Human Antizyme Gene,”Gene, 203, pp. 131-139; (1997).
Sylvie Aubert et al., “Analysis of TwoStaphylococcus epidermidisPlasmids Coding for Resistance to Streptogramin A,”Plasmid,40, pp. 238-242; (1998).
J. I. Ross et al., “Inducible Erythromycin Resistance inStaphlyococciis Encoded by a Member of the ATP-Binding Transport Super-Gene Family,”Molecular Microbiology, 4/7, pp. 1207-1214; (1990).
Joanna Clancy et al., “Molecular Cloning and Functional Analysis of a Novel Macrolide-Resistance Determinant,mefA,fromStreptococcus Pyogenes,” Molecular Microbiology, 22/5, pp. 867-879; (1996).
David Kovalic et al., “Methylation of Minimalist 23S rRNA Sequences in Vitro by ErmSF (TlrA) N-Methyltransferase,”Biochemistry, 34, pp. 15838-15844; (1995).
Gerard Lina et al., “Distribution of Genes Encoding Resistance to Macrolides, Lincosamides, and Streptogramins amongStaphylococci,” Antimicrobial Agents and Chemotherap., 43/5, pp. 1062-1066; (1999).
Jeanine Allignet and Névine El Solh “Characterization of a NewStaphylococcalGene,vgaB,Encoding a Putative ABC Transporter Conferring Resistance toStreptograminA and Related Compounds,”Gene, vol. 202, pp. 133-138; (1997).
Jeanine Allignet, et al. “Nucleotide Sequence of aStaphylococcalPlasmid Gene,vgb, Encoding a Hydrolase Inactivating the B Components of Virginiamycin-like Antibiotics,”Plasmid, vol. 20, pp. 271-275; (1988).
Marc Aumercier, et al. “RP 59500: a proposed mechanism for its bactericidal activity,”Journal of Antimicrobial Chemotherapy, vol. 30, Suppl. A, pp. 9-14; (1992).
N. El Solh, et al. “Epidermiological and Structural Studies ofStaphylococcus aureusR Plasmids Mediating Resistance to Tobramycin and Streptogramin,”Plasmid, vol. 4, pp. 117-120; (1980).
Maria Inmaculada Barrasa, et al. “Theard1Gene fromStretomyces capreolusEncodes a Polypeptide of the ABC-transporters Superfamily which Confers Resistance to the Aminonucleoside Antibiotic A201A,”European Journal of Biochemistry, vol. 228, pp. 562-569; (1995).
Veronique Blanc, et al. “Molecular Characterization and Transcriptional Analysis of a Multidrug Resistance Gene Cloned from the Pristinamycin-producing Organism,Streptomyces pristinaespiralis,” Molecular Microbiology, vol. 17, No. 5, pp. 989-999; (1995).
C. Cocito “Antibiotics of the Virginiamycin Family, Inhibitors Which Contain Synergistic Components,”Microbiological Reviews, vol. 43, No. 2, pp. 145-198; (1979).
M. Di Giambattista, et al. “The Molecular Basis of the Inhibitory Activities of Type A and Type B Synergimycins and Related Antibiotics on Ribosomes,”Journal of Antimicrobial Chemotherapy, vol. 24, pp. 485-507; (1989).
K.G.H. Dyke and S.P. Curnock, “The Nucleotide Sequence of a Small Cryptic Plasmid Found inStapylococcus aureusand its Relationship to other Plasmids,”FEMS Microbiology Letters, vol. 58, pp. 209-216; (1989).
J.M. Entenza, et al. “Treatment of Experimental Endocarditis Due to Erythromycin-Suscepitble or -Resistant Methicillin-ResistantStaphylococcus aureuswith RP 59500,”Antimicrobial Agents and Chemotherapy, vol. 39, No. 7, p. 1419-1424; (1995).
Bruno Fantin, et al. “Critical Influence of Resistance to Streptogramin B-Type Antibiotics on Activity of RP 59500 (Quinupristin-Dalfopristin) in Experimental Endocarditis Due toStaphylococcus aureus,” Antimicrobial Agents and Chemotherapy, vol. 39, No. 2, pp. 400-405; (1995).
J. Fernando Fierro, et al. “Streptogramins-inactivating Activity in Three Producer Streptomycetes,”FEMS Microbiology Letters, vol. 58, pp. 243-246; (1989).
Martin Geistlich, et al. “Characterization of a Novel Regulatory Gene Governing the Expression of a Polyketide Synthase Gene inStreptomyces ambofaciens,” Molecular Microbiology, vol. 6, No. 14, pp. 2019-2029; (1992).
Maria Griswold, et al. “Quinupristin-dalfopristin (RP 59500): An injectable streptogramin combination,”Am J Health-Syst Pharm, vol. 53, pp. 2045-2053; (1996).
Stephen Hyde, et al. “Structural Model of ATP-binding Proteins Associated with Cystic Fibrosis, Multidrug Resistance and Bacterial Transport,”Nature, vol. 346, pp. 362-365; (1990).
Jack Kyte and Russell Doolittle “A Simple Method for Displaying the Hydropathic Character of a Protein,”Journal of Molecular Biology, vol. 157, pp. 105-132; (1982).
Chang Han Kim, “Studies on Mikamycin B Lactonase: I. Degradation of Mikamycin B byStreptomyces mitakaensis,” The Journal of Antibioticsvol. XXVII No. 12, pp. 903-908; (1974).
Takeshi Kimura, et al. “Selective Unfolding of Erythroid Chromatin in the Region of the Active β-globin Gene,”Nature, vol. 306, pp. 709-712; (1983).
Nadia Liassine, Jeanine Allignet, Névine El Solh, et al. “Multiplicity of the Genes and Plasmids Conferring Resistance to Pristina-mycin inStaphylococciSelected in an Algerian Hospital,”Zentralblatt für Bakteriologie, vol. 286, pp. 389-399; (1997).
Ja
Allignet Jeanine
El Solh Névine
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Institut Pasteur
Minnifield N. M.
LandOfFree
Polynucleotides and their use for detecting resistance to... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polynucleotides and their use for detecting resistance to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotides and their use for detecting resistance to... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3511110