Polynucleotides and polypeptides encoded thereby distantly...

Details Polynucleotides and polypeptides encoded thereby distantly... Polynucleotides and polypeptides encoded thereby distantly...

2006-09-05

2006-09-05

LeGuyader, John L. (Department: 1635)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S455000, C536S023100, C536S023200

Reexamination Certificate

active

07101706

ABSTRACT:
The present invention relates to novel polynucleotides encoding polypeptides homologous to heparanase, nucleic acid constructs including these novel polynucleotides, genetically modified cells expressing the same, recombinant proteins encoded thereby and which may have heparanase or other glycosyl hydrolase activity, antibodies recognizing the recombinant proteins, oligonucleotides, analogs thereof and ribozymes derived from these polynucleotides.

REFERENCES:
patent: 5332671 (1994-07-01), Ferrara et al.
Marra, M. et al. The WashU-HHMI Mouse EST Project, Accession No. AI019269.
Vlodavsky et al, (1999). Mammalian heparanase: gene cloning, expression and function in tumor progression and matastasis. Nature Medicine, vol. 5, No. 7, Jul. 1999, pp. 793-802.

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