Polynucleotides and polypeptides associated with benign prostati

Details Polynucleotides and polypeptides associated with benign prostati Polynucleotides and polypeptides associated with benign prostati

1998-11-06

2000-04-11

Carlson, Karen Cochrane

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530329, 530330, 530300, C07K 1400

Patent

active

060489634

ABSTRACT:
Benign prostatic hypertrophy specific polynucleotides and polypeptides are provided. Methods of diagnosing benign prostatic hypertrophy using these polynucleotides and polypeptides are also provided. Human BPH1 polypeptides and DNA (RNA) encoding such BPH1 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such BPH1 for the treatment of prostate disease. Antagonists against such BPH1 and their use as a therapeutic to treat prostate disease are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the BPH1 and for detecting altered levels of the polypeptide in a host.

REFERENCES:
Hillier et al., "The WashU-Merck EST Project", GenBank Accession No. T47615, Feb. 1, 1995.
Hillier et al. "The WashU-Merck EST Project", GenBank Accession No. H57374, Oct. 5, 1995.
Murphy et al. "Comparison of Prostate Antigen, Prostate Specific Membrane Antigen, and LNCaP-Based Enzyme-Linked Immunosorbent Assays in Prostatic Cancer Patients and Patients with Benign Prostatic Enlargement", The Prostate, vol. 26, pp. 164-168 (1995).
Densel et al. "Detection of Prostate Specific Antigen Complexed to Alpha1-Antichymotrypson (PSA/ACT) and Uncomplexed PSA in Serum from Patients with Benign Prostate Hypertrophy (BPH) and Prostate Cancer (PCA) using Dual Monoclonal Immunoassays", The Journal of Urology, vol. 146, pp. 333A (1991).
Copy of Partial EP Search Report.

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