Polynucleotide reagents containing modified deoxyribose moieties

Details Polynucleotide reagents containing modified deoxyribose moieties Polynucleotide reagents containing modified deoxyribose moieties

1995-04-26

1997-01-14

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 221, 536 243, 435 6, C07H 2102, C07H 2104, C07H 1900, C12Q 168

Patent

active

055941176

ABSTRACT:
Methods and reagents are provided for synthesizing polynucleotides containing modified deoxyribose residues. Monomeric reagents having the structural formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined herein, are used to create polynucleotides having nonnucleotidic moieties --A--Z--(R.sup.9).sub.n at the 1 position of selected deoxyribose units. The polynucleotides so provided are useful in a variety of hybridization assay formats.

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