Polynucleotide purification method

Details Polynucleotide purification method Polynucleotide purification method

1997-09-15

1999-12-07

Crane, L. Eric

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, 536 2534, 536 2533, 536 231, C07H 2100

Patent

active

059986042

ABSTRACT:
A method of purifying a hydrophobically substituted polynucleotide by reverse phase HPLC is described. The hydrophobic substituent may be removed from the polynucleotide under non-acidic conditions; the purification method is thus especially useful for acid sensitive polynucleotide analogs.

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