Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-10-15
1995-09-26
Robinson, Douglas W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 243, 536 2431, 536 2432, C07H 2100, C07H 2102, C07H 2104
Patent
active
054534968
ABSTRACT:
Oligonucleotides having at least one phosphorodithioate internucleotide linkage. Phosphorodithioate oligonucleotides exhibit stronger antiviral activity than the corresponding phoshorothioate derivatives.
REFERENCES:
patent: 3451997 (1969-06-01), Fujimoto et al.
patent: 3687808 (1972-08-01), Merigan et al.
patent: 3846402 (1972-11-01), Eckstein et al.
patent: 3853844 (1974-12-01), Shuman et al.
patent: 4373071 (1983-02-01), Itakura et al.
patent: 4415732 (1983-11-01), Caruthers et al.
patent: 4458066 (1984-07-01), Caruthers et al.
patent: 4500707 (1985-02-01), Caruthers et al.
patent: 4668777 (1987-05-01), Caruthers et al.
patent: 4728730 (1988-03-01), Frey et al.
patent: 4806463 (1989-02-01), Goodchild et al.
patent: 4808708 (1989-02-01), Yoshida et al.
patent: 5278302 (1994-01-01), Caruthers et al.
Matsukura et al. Proc. Natl. Acad. Sci. vol. 84, pp. 7706-7710, 1987.
Stel et al. J. Am; Chem. Soc., vol. 106, pp. 6077-6079, 1984.
Eckstein, F. J. Am. Chem. Soc., vol. 92, No. 15, pp. 4718-4723, 1970.
Stein et al. Nucl. Acids Res., vol. 16, No. 8, pp. 3208-3221, 1988.
Froehler, B. C., Tetrahedron Letters, vol. 27, No. 46, pp. 5575-5578, 1986.
Chemical Abstracts (1979), vol. 91, No. 33, p. 623, Abstr. No. 74827a, Sekine et al. J. Org Chem., vol. 44, No. 13, pp. 2325-2326, 1978.
Brill Wolfgang
Caruthers Marvin H.
Marshall William S.
Nielsen John
Kunz Gary L.
Robinson Douglas W.
University Patents Inc.
LandOfFree
Polynucleotide phosphorodithioate does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polynucleotide phosphorodithioate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotide phosphorodithioate will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1552527