Polynucleotide encoding novel HCV non-structural polypeptide

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S320100, C424S228100

Reexamination Certificate

active

07449566

ABSTRACT:
Polypeptides comprising a mutant non-structural Hepatitis C virus useful in diagnostic and/or immunogenic compositions are disclosed, in which the mutant is an N-terminal mutation that functionally disrupts the catalytic domain of NS3. Polynucleotides encoding these polypeptides, host cells transformed with polynucleotides and methods of using the polypeptides and polynucleotides are also disclosed.

REFERENCES:
patent: 5371017 (1994-12-01), Houghton et al.
patent: 5683864 (1997-11-01), Choo et al.
patent: 5843752 (1998-12-01), Dasmahapatra et al.
patent: 6333186 (2001-12-01), Wittekind et al.
patent: 6800456 (2004-10-01), Wittekind et al.
patent: 0450931 (1991-10-01), None
patent: 0696640 (1996-02-01), None
patent: WO 93/09253 (1993-05-01), None
patent: WO 95/25122 (1995-09-01), None
patent: WO 99/07734 (1999-02-01), None
patent: WO 99/28482 (1999-06-01), None
patent: WO 99/38880 (1999-08-01), None
patent: WO 00/66623 (2000-11-01), None
Bartenschlager et al. Nonstructural Protein 3 of the Hepatitis C Virus Encodes a Serine-Type Proteinase Required for Cleavage at the NS3/4 and NS4/5 Junctions, J. Virology, Jul. 1993, vol. 67, pp. 3835-3844.
Botarelli et al., “T-Lymphocyte Response to Hepatitis C Virus in Different Clinical Courses of Infection,”Gastroentereology104:580-587 (1993).
Chen et al., “Human and murine antibody recognition is focused on the ATPase/helicase, but not the protease domain of the hepatitis C virus nonstructural 3 protein,”Hepatology28(1):219-224, 1998.
Cooper et al., “Analysis of a Successful Immune Response Against Hepatitis C Virus,”Immunity10:439-449 (1999).
Diepolder et al., “Possible Mechanism Involving T-lymphocype Response to Non-structural Protein 3 in Viral Clearance in Acute Hepatitis C Virus Infection,”Lancet346:1006-1007 (1995).
Diepolder et al., “Immunodominant CD4+ T-Cell Epitope Within Nonstructural Protein 3 in Acute Hepatitis C Virus Infection,”Journal of Virology71:6011-6019 (1997).
Farrari et al., “T-Cell-Response to Structural and Nonstructural Hepatitis C Virus Antigens in Persisitant and Self-Limited Hepatitis C Virus Infections,”Hepatology19:286-295(1994).
Hoffman et al., “Mapping of Immunodominant CD4+ Lymphocyte Epitopes of Hepatitis C Virus Antigens and their relevance During the Course of Chronic Infection,”Hepatology21:632-638 (1995).
Iwata et al., “Interferon Gamma Production by Peripheral Blood Lymphocytes to Hepatitus C Virus Core Protein in Chronic Hapatitis C Infection,”Hepatology22:1057-1064 (1995).
Minutello et al., “Compartmentalization of T Lymphocytes to the Site of Disease: Intrahepatic CD4+ T Cells Specific for the Protein NS4 of Hepatitis C Virus in Patients with Chronic Hepatitis C,”J. Exp. Med. 178:17-25 (1993).
Missale et al., “Different Clinical Behaviors of Acute Hepatitis C Virus Infection are Associated with Different Vigor of the Anti-viral Cell-mediated Immune Response,”J. Clin. Invest. 98:706-714 (1996).
Tsai et al., “Detection of Type 2-Like T-Helper Cells in Hepatitis C Virus Infection: Implications for Hepatitis C Virus Chronicity,”Hepatology25:449-458 (1997).
Tsai et al., “Cellular Imune Responses in Patients with Dual Infection of Hepatitis B and C Viruses: Dominant Role of Hepatitis C Virus,”Hepatology21:908:912 (1995).
Eckart et al., “The Hepatitis C Virus Encodes a Serine Protease Involved in Processing of the Putative Nonstructural Proteins from the Viral Polyprotein Precursor,” Biochem. Biophys. Research Comm., vol. 192, No. 2, Apr. 30, 1993, pp. 399-406.
Chien, et al., “Use of a Novel Hepatitus C Virus (HCV) Major-Epitope Chimeric Polypeptide For Diagnosis of HCV Infection,” J Clinical Microbiology 87:1393-1397 (1999).
Cho, et al., “Enhanced Cellular Immunity to Hepatitus C Virus Nonstructural Proteins by Codelivery of Granulocyte Macrophage-Colony Stimulating Factor Gene in Intramuscular DNA Immunization,”Vaccine17:9-10 (1999).
Clarke, “Molecular Virology of Hepatitus C Virus,”J Gen Virol78:2397-2410 (1997).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polynucleotide encoding novel HCV non-structural polypeptide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polynucleotide encoding novel HCV non-structural polypeptide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotide encoding novel HCV non-structural polypeptide will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4031671

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.