Polynucleotide encoding mu opioid receptor

Details Polynucleotide encoding mu opioid receptor Polynucleotide encoding mu opioid receptor

1997-07-07

2000-08-15

Kunz, Gary L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 701, 435 711, 435 712, 435325, 435471, 4352523, 4353201, 536 235, C12P 2106, C12P 2104, C12N 120, C12N 1574

Patent

active

061034924

ABSTRACT:
The invention relates generally to compositions of and methods for obtaining mu opioid receptor polypeptides. The invention relates as well to polynucleotides encoding mu opioid receptor polypeptides, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, recombinant opioid receptor polypeptides, and antibodies immunoreactive with mu opioid receptors. The invention includes as well, methods for using the isolated, recombinant receptor polypeptide in assays designed to select and improve substances capable of interacting with mu opioid receptor polypeptides for use in diagnostic, drug design and therapeutic applications.

REFERENCES:
patent: 5658783 (1997-08-01), Grandy et al.
Wang, FEBS Letters, 338, 217-222, 1994.
Fukuda, FEBS Letters, 343, 42-46, 1994.
Ueda, PNAS, 85, 7013-7017, 1988.
Lin, Science, 254, 1022-1024, 1991.
Dohlman, H.G., "Model Systems for the Study of Seven-Transmembrane-Segment Receptors," Annu. Rev. Biochem., 60:653-688, 1991.
Dohlman et al., "A Family of Receptors Coupled to Guanine Nucleotide Regulatory Proteins," Biochemistry, 26:2657-2664, 1987.
Evans et al., "Cloning of a Delta Opioid Receptor by Functional Expression," Science, 258:1952-1954, 1992.
Frielle, T. et al., "Structural Basis of .beta.-adrenergic Receptor Subtype Specificity Studied with Chimeric .beta.1/.beta.2-adrenergic Receptors," Proc. Natl. Acad. Sci. USA, 85:9494-9498, 1988.
Gioannini, T.L. et al., "Evidence for the Presence of Disulfide Bridges in Opioid Receptors Essential for Ligand Binding. Possible Role in Receptor Activation," J. Mol. Recogn., 2:44-48, 1989.
Kieffer et al., "The .delta.-opioid receptor: Isolation of a cDNA by Expression Cloning and Pharmacological Characterization," Proc. Natl. Acad. Sci. USA, 89:12048-12052, 1992.
Loh et al., "Molecular Characterization of Opioid Receptors," Annu. Rev. Pharmacol. Toxicol., 30:123-147, 1990.
Lutz et al., "Opioid Receptors and Their Pharmacological Profiles," J. Receptor Res., 12:267-286, 1992.
Mansour et al., "Anatomy of CNS Opioid Receptors," Trends in Neurosci., 7:2445-2453, 1987.
Nock et al., "Autoradiography of [3H]U-69593 Binding Sites in Rat Brain: Evidence for K Opioid Receptor Subtypes," Eur. J. Pharmacol., 154:27-34, 1988.
Simon, E.J., "Opioid Receptors and Endogenous Opioid Peptides," Medicinal Res. Rev., 11:357-374, 1991.
Unterwald et al., "Neuroanatomical Localization of K1 and K2 Opioid Receptors in Rat and Guinea Pig Brain," Brain Res., 562:57-65, 1991.
Xie et al., "Expression Cloning of cDNA Encoding a Seven-helix Receptor from Human Placenta with Affinity for Opioid Ligands," Proc. Natl. Acad. Sci. USA, 89:4124-4128, 1992.
Yamada et al., "Cloning and Functional Characterization of a Family of Human and Mouse Somatostatin Receptors Expressed in Brain, Gastrointestinal Tract, and Kidney," Proc. Natl. Acad. Sci. USA, 89:251-255, 1992.
Yasuda et al., "Cloning of a Novel Somatostatin Receptor, SSTR3, Coupled to Adenylcyclase," J. Biol. Chem., 267:20422-20428, 1992.
Schofield et al., "Molecular Characterization of a New Immunoglobulin Superfamily Protein with Potential Roles in Opioid Binding and Cell Contact," The EMBO Journal, 8:489-495, 1989.
Probst et al., "Sequence Alignment of the G-Protein Coupled Receptor Superfamily," DNA and Cell Biology, 11:1-20, 1992.
Dialog Search Report, pp. 1-14, printed May 24, 1994.
Chen et al., "Molecular Cloning and Functional Expression of a .mu.-Opioid Receptor from Rat Brain," Mol. Pharm., 44(1):8-12, 1993.
Fukuda et al., FEBS, 327:311, 1993.
Li et al., PNAS, 88:7739, 1991.
Maneckjee et al., "Characterization of a polyclonal antibody to the .mu. opioid receptor," Journal of Neuroimmunology, 17:199-208, 1988.
Mierendorf et al., "Gene Isolation by Screening Agtll Libraries with Antibodies," Methods in Enzymology, 152:458-469, 1987.
Sambrook et al., "Molecular Cloning," vol. 3, Chp. 16, 1987, Academic Press.
Lane et al., "Regulation of an opioid-binding protein in NG108-15 cells parallels regulation of .delta.-opioid receptors," Proc. Natl. Acad. Sci. USA, 89:11234-11238, 1992.
Lippman et al., "Opioid-binding cell adhesion molecule (OBCAM)-related clones from a rat brain cDNA library," Gene, 117:249-254, 1992.
Chen et al., "Molecular cloning of a rat .kappa. opioid receptor reveals sequence similarities to the .mu. and .delta. opioid receptors," Biochem. J., 295:625-628, 1993.
Li et al., "Purification of Opioid Receptor in the Presence of Sodium Ions," Life Sciences, 51(15):1177-1185, 1992.
Fujioka et al., "Purification and reconstitution of .mu.-opioid receptors in liposome," J. Chromat., 597:429-433, 1992.
Chen et al., "Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family," FEBS Lett., 347:279-283, 1994.
Chen and Yu, "Differential Regulation by cAMP-dependent Protein Kinase and Protein Kinase C of the .mu. Opioid Receptor Coupling to a G Protein-activated K.sup.+ Channel," J. Biol. Chem., 269(11):7839-7842, 1994.
Soong et al., "Structure and Functional Expression of a Member of the Low Voltage-Activated Calcium Channel Family," Science, 260:1133-1136, 1993.
Carlson et al., "Thrombin and phorbol esters cause the selective phosphorylation of a G protein other than G.sub.i in human platelets," J. Biol. Chem., 264:13298-13305, 1989.

Affiliated with

Also associated with

Rating

Polynucleotide encoding mu opioid receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polynucleotide encoding mu opioid receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotide encoding mu opioid receptor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2005220