Polynucleotide encoding IL-6 receptor/IL-6 fusion protein

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S254230, C536S023400, C530S416000, C530S417000

Reexamination Certificate

active

07901911

ABSTRACT:
The present invention intends to provide an IL-6R.IL-6 fusion protein and the like in which IL-6R and IL-6 are directly linked without a linker.The IL-6 receptor.IL-6 fusion protein of the present invention has a structure in which one amino acid residue constituting IL-6 receptor and one amino acid residue constituting IL-6 are directly bonded.

REFERENCES:
patent: 11-196867 (1999-07-01), None
patent: 99/02552 (1999-01-01), None
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Hollenberg et al,Current Opinion in Biotechnology, 8:554-560 (1997).
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Voet et al,Biochemistry, John Wiley & Sons, Inc., pp. 126-128 and 228-234 (1990).
Renne et al,J. Biol. Chem., 273(42):27213-27219 (1998).
Jostock et al,J. of Immunological Methods, 223(2):171-183 (1999).
Chebath et al,European Cytokine Network, John Libbey Eurotext Ltd., Montrouge, Fr., 8(4):359-365 (1997).
Kollet et al,Blood, 90(10):394A (1997).

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