Polynucleotide encoding human Myt-1 kinase clone

Details Polynucleotide encoding human Myt-1 kinase clone Polynucleotide encoding human Myt-1 kinase clone

1997-10-01

1999-08-10

Teng, Sally P.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 691, 4352523, 43525411, 435325, 536 232, 536 235, C12N 1554, C12N 912

Patent

active

059358351

ABSTRACT:
Human Myt-1 kinase polypeptides and DNA (RNA) encoding such enzyme and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such human Myt-1 kinase in the development of treatments for cancers, such as leukemias, solid tumors and metastases; chronic inflammatory proliferative diseases, such as psoriasis and rheumatoid arthritis; proliferative cardiovascular diseases, such as restenosis; proliferative ocular disorders, such as diabetic retinopathy and macular degeneration; and benign hyperproliferative diseases, such as benign prostatic hypertrophy and hemangiomas, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides.

REFERENCES:
patent: 5744349 (1998-04-01), Piwnica-worms
George et al., Macromolecular Sequencing and Synthesis, Selected Methods and Applications, pp. 127-149, 1988, Alan R. Liss, Inc.
Mueller, P. et al., "Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15", Science, vol. 270, pp. 86-90 (1995).
Atherton-Fessler, S. et al., "Cell Cycle Regulation of the p34.sup.cdc2 Inhibitory Kinases", Mol. Biol. Cell, vol. 5 (9), pp. 989-1001 (1994).
Liu,Feng, et al. "The Human Myt1 Kinase Preferentially Phosphorylates Cdc2 on Threonine 14 and Localizes to the Endoplasmic Reticulum and Golgi Complex", Molecular and Cellular Biology, vol. 17 (2) pp. 571-583, Feb., 1997.
Booher, Robert N., "Human Myt1 Is a Cell Cycle-regulated Kinase That Inhibits Cdc2 but Not Cdk2 Activity", The Journal of Biological Chemistry, vol. 272 (35), pp. 22300-22306, Aug. 29, 1997.

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