Polynucleotide encoding human lysyl hydroxylase-like protein

Details Polynucleotide encoding human lysyl hydroxylase-like protein Polynucleotide encoding human lysyl hydroxylase-like protein

1997-12-12

2000-10-10

Ungar, Susan

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4353201, 4352523, 435 691, 536 231, C12Q 168, C12N 1500, C12N 121, C12N 1511

Patent

active

06130039&

ABSTRACT:
The invention provides a human lysyl hydroxylase-like protein (HLHLP) and polynucleotides which identify and encode HLHLP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HLHLP.

REFERENCES:
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Hyland, J., et al., "A homozygous stop codon in the lysyl hydroxylase gene in two siblings with Ehlers-Danlos syndrome type VI," Nature Genetics, 2:228-231 (1992).
Hautala, T., et al., "A Large Duplication in the Gene for Lysyl Hydroxylase Accounts for the Type VI Variants of Ehlers-Danlos Syndrome in Two Siblings," Genomics, 15:399-404 (1993).
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Valtavaara, M., et al., (GI 2138313), GenBank Sequence Database (Accession U84573), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894, 1997.
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Hautala, T., et al., (GI 190074), GenBank Sequence Database (Accession L06419), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894, 1995.
Hautala, T., et al., "Cloning of Human Lysyl Hydroxylase: Compete cDNA-Derived Amino Acid Sequence and Assignment of the Gene (PLOD) to Chromosome 1p36.3.fwdarw.p.36.2," genomics, 13:62-69 (1992).
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