Polynucleotide encoding a human receptor tyrosine kinase

Details Polynucleotide encoding a human receptor tyrosine kinase Polynucleotide encoding a human receptor tyrosine kinase

2005-11-29

2005-11-29

Mertz, Prema (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S071100, C435S071200, C435S325000, C435S471000, C435S320100, C435S252300, C435S254110, C536S023500

Reexamination Certificate

active

06969596

ABSTRACT:
An isolated and purified human receptor tyrosine kinase is described. A cDNA sequence which encodes the native polypeptide is disclosed as well as the structural coding region and the amino acid residue sequence of the tyrosine kinase. Methods are provided which employ novel sequences to identify compounds that modulate the biological and/or pharmacological activity of the tyrosine kinase and hence regulate cellular and tissue physiology. Biologically-effective antisense molecules, as well as dominant negative mutant versions of the kinase, are described which are suitable for therapeutic use. The invention is also related to the diagnosis, study, prevention, and treatment of pathophysiological disorders related to or mediated by the biological molecule.

REFERENCES:
patent: 5763198 (1998-06-01), Hirth et al.
patent: 5763441 (1998-06-01), App et al.
patent: 5763470 (1998-06-01), Tang et al.
patent: 5763584 (1998-06-01), Godowski
patent: WO 95/30331 (1995-11-01), None
patent: WO 97/34920 (1997-09-01), None
Shawver et al., 1997, Receptor tyrosine kinases as targets for inhibition of angiogenesis, Drug Discovery Today, 2:50-63.
Herz et al., 1997, Molecular approaches to receptors as targets for drug discovery, J. Recept. Signal Transduct. Res., 17:671-776.
Marra et al., The WashU-HHMI mouse EST project, EMBL ACC NO AA098024, Oct. 27, 1996.
Auffray et al., IMAGE: integrated molecular analysis of the human genome and its expression, EMBL ACC NO Z42722, Nov. 6, 1994.
Rubin Grandis et al., Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells, Oncogene, 15:409-416.
Chou et al., 1987, Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin, J. Bio. Chem., 262:1842-1847.
Mikayama et al., Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor, Proc. Natl. Acad. Sci., 1993, pp. 10056-10060, vol. 90.
Voet et al., Biochemistry, pp. 126-128, 228-234, John Wiley & Sons, Inc. 1990.

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