Polynucleotide determination with selectable cleavage sites

Details Polynucleotide determination with selectable cleavage sites Polynucleotide determination with selectable cleavage sites

1984-10-16

1988-10-04

Warren, Charles F.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435803, 435810, 435 91, 935 78, 436501, 436527, 536 27, G12Q 168, G01N 33566, C12P 1934

Patent

active

047756195

ABSTRACT:
Methods for diagnosis employing polynucleotides having oligonucleotide sequences substantially homologous to a sequence of interest, where the presence or absence of hybridization at a predetermined stringency provides for the release of a label from a support. Particularly, various techniques are employed for binding a label to a support, whereupon cleavage of either a single or double strand, a label may be released from a support, where the release of the label can be detected as indicative of the presence of a particular oligonucleotide sequence in a sample. The method finds use in diagnosis of disease, genetic monitoring, and analyzing nucleic acid mixtures.

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