Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-07-27
1999-01-12
Low, Christopher S.F.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
514 44, 514 6, 5141723, 514325, 514 911, 514 12, C07H 2104
Patent
active
058592261
ABSTRACT:
The invention is directed to a newly discovered class of polynucleotide decoys that is capable of competitively inhibiting the binding of transcription factors to the X-box sequence. This binding is necessary for the expression of MHC-II genes. The invention is also directed to methods of preparing these polynucleotide decoys, and methods of use thereof. In particular, we have identified a class of polynucleotide decoys that mimic the X-Box of MHC-II and competitively bind the MHC-II transcription factor RF-X, resulting in the modulation of MHC-II antigen expression. Thus, the invention can be used to inhibit the expression of HLA molecules on the surface of donor cells or organs, in order to render them invisible to the host's immune system, or in methods of treating an individual with an autoimmune disease characterized by dysfunctional expression of an MHC class II antigen. Further, because of the role of RF-X in the expression of several viral proteins, the polynucleotide decoys of the invention can be used in methods of treating an individual infected with hepatitis B virus, or cytomegalovirus.
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Garovoy Marvin R.
Hunt C. Anthony
Lim Carol
Low Christopher S.F.
Nguyen Dave Trong
Regents of the University of California, The
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