Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2005-05-24
2005-05-24
Ketter, James (Department: 1636)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S069100, C514S04400A, C536S023100
Reexamination Certificate
active
06897068
ABSTRACT:
Disclosed is a complex for providing nucleic acid expression in a cell. A polynucleotide and a polymer are mixed together to form the complex wherein the zeta potential of the complex is not positive. Then the complex is delivered to the cell wherein the nucleic acid is expressed.
REFERENCES:
patent: 6379966 (2002-04-01), Monahan et al.
Simoes et al., Gene Therapy, vol. 5, 1998, pp. 955-964.*
Birchall et al., International Journal of Pharmaceutics, vol. 183, 199, pp. 195-207.
Budker Vladimir G.
Hagstrom James E.
Monahan Sean D.
Rozema DAvid B.
Slattum Paul M.
Johnson Mark K.
Ketter James
Mirus Bio Corporation
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