Polynucleotide cleavage agent switched on by photo irradiation

Details Polynucleotide cleavage agent switched on by photo irradiation Polynucleotide cleavage agent switched on by photo irradiation

2006-08-29

2006-08-29

Riley, Jezia (Department: 1637)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C560S124000, C435S006120, C536S023100

Reexamination Certificate

active

07098245

ABSTRACT:
The present invention provides a polynucleotide cleavage agent switched on by photo-irradiation and a method of cleaving or decomposing a polynucleotide such as DNA or RNA using this agent switched on in this manner. More specifically, said polynucleotide cleavage agent switched on by photo-irradiation comprises cyclopropane or a 2,2-dihalogeno-cyclopropane ring between “A” unit and “B” unit, wherein said “A” unit is an aromatic group having an electron withdrawing property and is excited by photo-irradiation, and said “B” unit is a hydrophilic functional group. Said polynucleotide cleavage agent may further contain “C” unit which can recognize DNA sequences, and also a spacer molecule, if desired.

REFERENCES:
Ly, D. et al, J. Am. Chem Soc. 118, 8747-8748 (1996).
Kumar, C.V. et al, Tetrahedron, 56, 7027-7040 (2000).
Toshima, K et al, Bioorganic & Medicinal Chemistry Letters 10, 2163-2165 (2000).
Toshima, K. et al, Chem. Commun. 3, 212-213 (2002).
Itoh, T. et al, “Synthesis of gem-Difluorocyclopropane Derivatives and Investigation on their DNA cleavage Property”, 81stAnnual Meeting of the Chemical Society of Japan, 2002 (Mar. 11, 2002).
Itoh, T. et al “Synthesis of gem-Difluorocyclopropane Derivatives and Investigation on their Bioactivities” Abstracts of the 25thFlourine Conference of Japan (Nov. 18-20, 2001).

Affiliated with

Also associated with

Rating

Polynucleotide cleavage agent switched on by photo irradiation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polynucleotide cleavage agent switched on by photo irradiation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotide cleavage agent switched on by photo irradiation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3696867