Polynucleotide and protein involved in synaptogenesis,...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C530S387900, C435S006120, C435S007100

Reexamination Certificate

active

07906640

ABSTRACT:
The invention relates to a kit for diagnosing autism linked to a mutation in a protein belonging to the family of human neuroligins.

REFERENCES:
patent: 99/55915 (1999-11-01), None
patent: WO 99/55915 (1999-11-01), None
U.S. Appl. No. 11/932,220, filed Oct. 31, 2007, Bourgeron, et al.
Anne Philippe, et al., “Genome-wide scan for autism susceptibility genes”, Human Molecular Genetics, vol. 8, No. 5, pp. 805-812, 1999.
N. Simon Thomas, et al., “Xp deletions associated with autism in three females”, Hum. Genet., vol. 104, pp. 43-48, 1999.
Jeff Milunsky, et al., “Schizophrenia susceptibility gene locus at Xp22.3”, Clinical Genetics, vol. 55, pp. 455-460, 1999.
Peter Scheiffele, et al., “Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons”, Cell, vol. 101, pp. 657-669.
Konstantin Ichtchenko, et al., “Neuroligin 1: A splice site-specific lingand for β-neurexins”, Cell, vol. 81, pp. 435-443, May 5, 1995.
Konstantin Ichtchenko, et al., “Structures, alternatives splicing, and neurexin binding of multiple neuroligins”, The Journal of Biological Chemistry, vol. 271, No. 5, pp. 2676-2682, Feb. 2, 1996.
Marc F. Bolliger, et al., “Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression”, Biochem. J. vol. 356, pp. 581-588.
Mirta Grifman, et al., “Functional redundancy of acetycholinesterase and neuroligin in mammalian neuritogenesis,” Proc. Natl. Acad. Sci. USA, vol. 95, pp. 13935-13940, 1998.
M. Irie, et al., “Binding of neuroligins to PSD-95,” Science, vol. 277, pp. 1511-1515, Sep. 5, 1997.
Kazuyo Hirao, et al., “A novel multiple PDZ domain-containing molecule interacting with N-methyl-d-aspartate receptors and neuronal cell adhesion proteins”, The journal of Biological Chemistry, vol. 273, No. 33, pp. 21105-21110, Aug. 14, 1998.
Cornelia Kurschner, et al., “CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins”, Molecular and Cellular Neuroscience, vol. 11, No. 3, pp. 161-172, 1998.
Kazuhiko Toyooka, et al., “Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophrenia”, Journal of Neurochemistry, vol. 83, No. 4, pp. 797-806, 2002.
G. Kohler, et al., “Continuous cultures of fused cells secreting antibody of predefined specificity”, Nature, vol. 256, pp. 495-497, Aug. 7, 1975.
2003 Nature Publishing Group, vol. 34, pp. 27-29, “Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism”.
Robert A Philibert, et al., Gene 246 (2000) pp. 303-310, “The structure and expression of the human neuroligin-3 gene”.
Grifman M et al. Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis PNAS USA, 1998; 95:13935-13940.
Vincent JB et al. Mutation screenin of X-chromosome neuroligin genes: No mutations in 196 probands. Am J Med Genet B Neuropsychiatric Genet 2004; 129B: 82-84.
Ylisaukko-oja T et al. Analysis of four neuroligin genes as candidates for autism. Eur J Human Genetics, 2005; 13: 1285-1292.
Abdolmaleky HM et al. Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope. Am J. Pharmacogenomics, 2005: 5(3): 149-160.
Cline H. Synaptogenesis: A balancing act between excitation and inhibition. Curr Biol. 2004; 15(6): R203-R205.
Dean C & Dresbach T. Neuroligins and neurexins: Linking cell adhesion, synapse formation and cognitive function. Trends Neurosci, 2006; 29(1): 21-29.
Gauthier J et al. NLGN3/NLSG4 Gene mutations are not responsible for autism in the Quebec population. Am J Med Genet B Neuropsychiatric Genet, 2005; 132(1): 74-75.

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