Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-07-22
2000-02-15
Sisson, Bradley
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 231, 4352523, 4352542, 435348, 435410, 435325, 4353201, C12P 2106, C07H 2102, C12N 120, C12N 1500, C12N 114
Patent
active
060251603
ABSTRACT:
Rat mdr1b2 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize rat mdr1b2. Further disclosed is method for performing a selection screen, whereby compounds are discovered that neither agonize nor antagonize rat mdr1b2.
REFERENCES:
Watson et al. Recombinant DNA, 2nd edition. Scientific American Books, WH Freeman and Company, pp. 453-470, 1992.
Public Database Accession Nos. M81855, M62425.
Silverman, et al., "Cloning and characterization a member of the rat multidrug resistance (mdr) gene family," Gene 106: 229-236, (1991).
Brun Kimberly A
Chenery Richard J
Ellens Harma
Feild John A
Yue Lin
Han William T.
King William T.
Sisson Bradley
SmithKline Beecham Corporation
Srivastava Devesh
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