Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-02-13
2007-02-13
Saidha, Tekchand (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S004000, C435S006120, C530S300000, C530S350000
Reexamination Certificate
active
10617351
ABSTRACT:
In general, this invention relates to nucleic acid and amino acid sequences involved in fat metabolism regulation and the use of these sequences as targets for the diagnosis, treatment, and prevention of obesity and obesity-related diseases. In addition, the invention relates to screening methods for identifying modulators of body fat metabolism and the development of treatments for obesity and obesity-related diseases.
REFERENCES:
patent: 2004/0197766 (2004-10-01), Gu et al.
Yip et al. Life Sciences (2000) 66(2): 91-103.
Adibi, “The Oligopeptide Transporter (Pept-1) in Human Intestine: Biology and Function,”Gastroenterology113:332-340 (1997).
Adibi, “Regulation of Expression of the Intestinal Oligopeptide Transporter (Pept-1) in Health and Disease,”Am. J. Physiol. Gastrointest. Liver Physiol.285: G779-G788 (2003).
Aschenbach et al., “Effect of AICAR Treatment on Glycogen Metabolism in Skeletal Muscle,”Diabetes51:567-573 (2002).
Brown et al., “Calcium Cages, Acid Baths and Recycling Receptors,”Nature388:629-630 (1997).
Chawla et al., “Nuclear Receptors and Lipid Physiology: Opening the X-Files,”Science294:1866-1870 (2001).
Chin, “On the Preparation and Utilization of Isolated and Purified Oligonucleotides,” Description of CD-ROM deposited in the public collection of the Kathrine R. Everett Law Library of the University of North Carolina, Mar. 14, 2002.
Chin, “On the Preparation and Utilization of Isolated and Purified Oligonucleotides,” Copy of CD-ROM deposited in the public collection of the Kathrine R. Everett Law Library of the University of North Carolina, Mar. 14, 2002.
Comings et al., “The Dopamine D2Receptor (DRD2) as a Major Gene in Obesity and Height,”Biochem Med Metab. Biol.50:176-185 (1993).
Contreras et al., “Dopamine, Hypertension and Obesity,”J. Hum. Hypertens.16 Suppl 1:S13-17 (2002).
Friedman et al., “Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription and Hyperglycemia are Regulated by Glucocorticoids in Genetically Obesedb/dbTransgenic Mice,”J. Biol. Chem.272:31475-31481 (1997).
Frykman et al., “Normal Plasma Lipoproteins and Fertility in Gene-Targeted Mice Homozygous for a Disruption in the Gene Encoding Very Low Density Lipoprotein Receptor,”Proc. Natl. Acad. Sci. USA92:8453-8457 (1995).
GenBank Accession No. C62139.
Geourjon et al., “A Common Mechanism for ATP Hydrolysis in ABC Transporter and Helicase Superfamilies,”Trends Biochem. Sci.26:539-544 (2001).
Good et al., “Hypogonadism and Obesity in Mice with a Targeted Deletion of theNhlh2Gene,”Nat. Genet.15:397-401 (1997).
Gottlieb and Ruvkun, “daf-2, daf-16 and daf-23: Genetically Interacting Genes Controlling Dauer Formation inCaenorhabditis elegans,” Genetics137:107-120 (1994).
Grant et al., “Evidence that RME-1, a ConservedC. elegansEH-Domain Protein, Functions in Endocytic Recycling,”Nat. Cell. Biol.3:573-579 (2001).
Greenspan et al., “Nile Red: a Selective Fluorescent Stain for Intracellular Lipid Droplets,”J. Cell. Biol.100:965-973 (1985).
Greenspan and Fowler, “Spectrofluorometric Studies of the Lipid Probe, Nile Red,”J. Lipid. Res.26:781-789 (1985).
Hanson and Reshef, “Regulation of Phosphoenolpyruvate Carboxykinase (GTP) Gene Expression,”Ann. Rev. Biochem.66:581-611 (1997).
Hardie and Carling, “The AMP-Activated Protein Kinase—Fuel Gauge of the Mammalian Cell?”Eur. J. Biochem.246:259-273 (1997).
Hardie et al., “The AMP-Activated/SNF1 Protein Kinase Subfamily: Metabolic Sensors of the Eukaryotic Cell?,”Ann. Rev. Biochem.67:821-855 (1998).
Holland and Blight, ABC-ATPases, Adaptable Energy Generators Fuelling Transmembrane Movement of a Variety of Molecules in Organisms from Bacteria to Humans,J. Mol. Biol.293:381-399 (1999).
Ioannou, “Multidrug Permeases and Subcellular Cholesterol Transport,”Nature Reviews2:657-668 (2001).
Lazar, “Becoming Fat,”Genes Dev.16:1-5 (2002).
Lin et al., “Rme-1 Regulates the Distribution and Function of the Endocytic Recycling Compartment in Mammalian Cells,”Nat. Cell. Biol.3:567-572 (2001).
McKenna and O'Malley, “Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators,”Cell108:465-474 (2002).
Nimpf and Schneider, “The VLDL Receptor: an LDL Receptor Relative with Eight Ligand Binding Repeats, LR8,”Atherosclerosis141:191-202 (1998).
Noben-Trauth et al., “A Candidate Gene for the Mouse Mutation Tubby,”Nature380:534-538 (1996).
Olswang et al., “A Mutation in the Peroxisome Proliferator-Activated Receptor γ-Binding Site in the Gene for the Cytosolic Form of Phosphoenolpyruvate Carboxykinase Reduces Adipose Tissue Size and Fat Content in Mice,”Proc. Natl. Acad. Sci. USA99:625-630 (2002).
Ogg et al., “The Fork Head Transcription Factor DAF-16 Transduces Insulin-Like Metabolic and Longevity Signals inC. elegans,” Nature389:994-999 (1997).
Pages et al., “LPA as a Paracrine Mediator of Adipocyte Growth and Function,”Ann. NY Acad. Sci.905:159-164 (2000).
Paradis et al., “A PDK1 Homolog is Necessary and Sufficient to Transduce AGE-1 PI3 Kinase Signals that Regulate Diapause inCaenorhabditis elegans,” Genes Dev.13:1438-1452 (1999).
Patterson et al., “The DAF-3 Smad Protein Antagonizes TGF-β-Related Receptor Signaling in theCaenorhabditis elegansDauer Pathway,”Genes Dev.11:2679-2690 (1997).
Rolland et al., “Evidence of Increased Glyceraldehyde-3-Phosphate Dehydrogenase and Fatty Acid Synthetase Promoter Activities in Transiently Transfected Adipocytes from Genetically Obese Rats,”J. Biol. Chem.270:1102-1106 (1995).
Sze et al., “Food and Metabolic Signalling Defects in aCaenorhabditis elegansSerotonin-Synthesis Mutant,”Nature403:560-564 (200).
Tacken et al., “Living up to a Name: the Role of the VLDL Receptor in Lipid Metabolism,”Curr. Opin. Lipidol.12:275-279 (2001).
Tecott et al., “Eating Disorder and Epilepsy in Mice Lacking 5-HT2cSerotonin Receptors,”Nature374:542-546 (1995).
Tissenbaum and Ruvkun, “An Insulin-like Signaling Pathway Affects both Longevity and Reproduction inCaenorhabditis elegans,” Genetics148:703-717 (1998).
Trommsdorff et al., “Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2,”Cell97:689-701 (1999).
Van Helvoort et al., “MDR1 P-Glycoprotein is a Lipid Translocase of Broad Specificity, while MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine,”Cell87:507-517 (1996).
Watts and Browse, “Isolation and Characterization of a Δ5-Fatty Acid Desaturase fromCaenorhabditis elegans,” Arch. Biochem. Biophys.362:175-182 (1999).
Watts and Browse, “Genetic Dissection of Polyunsaturated Fatty Acid Synthesis inCaenorhabditis elegans,” Proc. Natl. Acad. Sci. USA99:5854-5859 (2002).
Willson et al., “Peroxisome Proliferator-Activated Receptor γ and Metabolic Disease,”Ann. Rev. Biochem.70:341-367 (2001).
Wolkow et al., “Regulation ofC. elegansLife-Span by Insulinlike Signaling in the Nervous System,”Science290:147-150 (2000).
Yamagata et al., “Mutations in the Hepatocyte Nuclear Factor-4α Gene in Maturity-Onset Diabetes of the Young (MODY1),”Nature384:458-460 (1996).
Yoon et al., “Control of Hepatic Gluconeogenesis Through the Transcriptional Coactivator PGC-1,”Nature413:131-138 (2001).
Ashrafi Kaveh
Ruvkun Gary
Clark & Elbing LLP
Saidha Tekchand
The General Hospital Corporation
LandOfFree
Polynucleotide and polypeptide fat metabolism regulators and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polynucleotide and polypeptide fat metabolism regulators and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotide and polypeptide fat metabolism regulators and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3883607